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10.3389/fimmu.2021.693938 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.693938 34790191!8592035!34790191     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 693938 Nephropedia Template TP {{tp|p=34790191|t=2021. COVID-19 Mechanisms in the Human Body-What We Know So Far |pdf=|usr=}}{{34790191}} gab.com Text COVID-19 Mechanisms in the Human Body-What We Know So Far JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34790191 #FOAvip More than one and a half years have elapsed since the commencement of the coronavirus disease 2019 (COVID-19) pandemic, and the world is struggling to contain it. Being caused by a previously unknown virus, in the initial period, there had been an extreme paucity of knowledge about the disease mechanisms, which hampered preventive and therapeutic measures against COVID-19. In an endeavor to understand the pathogenic mechanisms, extensive experimental studies have been conducted across the globe involving cell culture-based experiments, human tissue organoids, and animal models, targeted to various aspects of the disease, viz., viral properties, tissue tropism and organ-specific pathogenesis, involvement of physiological systems, and the human immune response against the infection. The vastly accumulated scientific knowledge on all aspects of COVID-19 has currently changed the scenario from great despair to hope. Even though spectacular progress has been made in all of these aspects, multiple knowledge gaps are remaining that need to be addressed in future studies. Moreover, multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have emerged across the globe since the onset of the first COVID-19 wave, with seemingly greater transmissibility/virulence and immune escape capabilities than the wild-type strain. In this review, we narrate the progress made since the commencement of the pandemic regarding the knowledge on COVID-19 mechanisms in the human body, including virus-host interactions, pulmonary and other systemic manifestations, immunological dysregulations, complications, host-specific vulnerability, and long-term health consequences in the survivors. Additionally, we provide a brief review of the current evidence explaining molecular mechanisms imparting greater transmissibility and virulence and immune escape capabilities to the emerging SARS-CoV-2 variants. Twit Text FOAVip COVID-19 Mechanisms in the Human Body-What We Know So Far ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34790191 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34790191 #FOAvip English Wikipedia <ref>{{Cite pmid|34790191}}</ref> COVID-19 Mechanisms in the Human Body-What We Know So Far #MMPMID34790191 Kumar A; Narayan RK; Prasoon P; Kumari C; Kaur G; Kumar S; Kulandhasamy M; Sesham K; Pareek V; Faiq MA; Pandey SN; Singh HN; Kant K; Shekhawat PS; Raza K; Kumar S Front Immunol 2021[]; 12 (ä): 693938 PMID34790191show ga More than one and a half years have elapsed since the commencement of the coronavirus disease 2019 (COVID-19) pandemic, and the world is struggling to contain it. Being caused by a previously unknown virus, in the initial period, there had been an extreme paucity of knowledge about the disease mechanisms, which hampered preventive and therapeutic measures against COVID-19. In an endeavor to understand the pathogenic mechanisms, extensive experimental studies have been conducted across the globe involving cell culture-based experiments, human tissue organoids, and animal models, targeted to various aspects of the disease, viz., viral properties, tissue tropism and organ-specific pathogenesis, involvement of physiological systems, and the human immune response against the infection. The vastly accumulated scientific knowledge on all aspects of COVID-19 has currently changed the scenario from great despair to hope. Even though spectacular progress has been made in all of these aspects, multiple knowledge gaps are remaining that need to be addressed in future studies. Moreover, multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have emerged across the globe since the onset of the first COVID-19 wave, with seemingly greater transmissibility/virulence and immune escape capabilities than the wild-type strain. In this review, we narrate the progress made since the commencement of the pandemic regarding the knowledge on COVID-19 mechanisms in the human body, including virus-host interactions, pulmonary and other systemic manifestations, immunological dysregulations, complications, host-specific vulnerability, and long-term health consequences in the survivors. Additionally, we provide a brief review of the current evidence explaining molecular mechanisms imparting greater transmissibility and virulence and immune escape capabilities to the emerging SARS-CoV-2 variants. |Animals[MESH] |COVID-19/*immunology/*virology[MESH] |Host Microbial Interactions/*immunology[MESH] |Human Body[MESH] |Humans[MESH] |Lung/immunology/virology[MESH] |Pandemics/prevention & control[MESH]COVID-19 Mechanisms in the Human Body-What We Know So Far (epmc).pdf DeepDyve Pubget Overpricing