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Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nature 2021 ; 600 (7887): 133-137 Nephropedia Template TP
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Independent infections of porcine deltacoronavirus among Haitian children #MMPMID34789872
Lednicky JA; Tagliamonte MS; White SK; Elbadry MA; Alam MM; Stephenson CJ; Bonny TS; Loeb JC; Telisma T; Chavannes S; Ostrov DA; Mavian C; Beau De Rochars VM; Salemi M; Morris JG Jr
Nature 2021[Dec]; 600 (7887): 133-137 PMID34789872show ga
Coronaviruses have caused three major epidemics since 2003, including the ongoing SARS-CoV-2 pandemic. In each case, the emergence of coronavirus in our species has been associated with zoonotic transmissions from animal reservoirs(1,2), underscoring how prone such pathogens are to spill over and adapt to new species. Among the four recognized genera of the family Coronaviridae, human infections reported so far have been limited to alphacoronaviruses and betacoronaviruses(3-5). Here we identify porcine deltacoronavirus strains in plasma samples of three Haitian children with acute undifferentiated febrile illness. Genomic and evolutionary analyses reveal that human infections were the result of at least two independent zoonoses of distinct viral lineages that acquired the same mutational signature in the genes encoding Nsp15 and the spike glycoprotein. In particular, structural analysis predicts that one of the changes in the spike S1 subunit, which contains the receptor-binding domain, may affect the flexibility of the protein and its binding to the host cell receptor. Our findings highlight the potential for evolutionary change and adaptation leading to human infections by coronaviruses outside of the previously recognized human-associated coronavirus groups, particularly in settings where there may be close human-animal contact.