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10.1038/s41586-021-04111-z

http://scihub22266oqcxt.onion/10.1038/s41586-021-04111-z
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suck abstract from ncbi


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pmid34789872      Nature 2021 ; 600 (7887): 133-137
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  • Independent infections of porcine deltacoronavirus among Haitian children #MMPMID34789872
  • Lednicky JA; Tagliamonte MS; White SK; Elbadry MA; Alam MM; Stephenson CJ; Bonny TS; Loeb JC; Telisma T; Chavannes S; Ostrov DA; Mavian C; Beau De Rochars VM; Salemi M; Morris JG Jr
  • Nature 2021[Dec]; 600 (7887): 133-137 PMID34789872show ga
  • Coronaviruses have caused three major epidemics since 2003, including the ongoing SARS-CoV-2 pandemic. In each case, the emergence of coronavirus in our species has been associated with zoonotic transmissions from animal reservoirs(1,2), underscoring how prone such pathogens are to spill over and adapt to new species. Among the four recognized genera of the family Coronaviridae, human infections reported so far have been limited to alphacoronaviruses and betacoronaviruses(3-5). Here we identify porcine deltacoronavirus strains in plasma samples of three Haitian children with acute undifferentiated febrile illness. Genomic and evolutionary analyses reveal that human infections were the result of at least two independent zoonoses of distinct viral lineages that acquired the same mutational signature in the genes encoding Nsp15 and the spike glycoprotein. In particular, structural analysis predicts that one of the changes in the spike S1 subunit, which contains the receptor-binding domain, may affect the flexibility of the protein and its binding to the host cell receptor. Our findings highlight the potential for evolutionary change and adaptation leading to human infections by coronaviruses outside of the previously recognized human-associated coronavirus groups, particularly in settings where there may be close human-animal contact.
  • |Amino Acid Sequence[MESH]
  • |Animals[MESH]
  • |Bayes Theorem[MESH]
  • |Child[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Conserved Sequence[MESH]
  • |Coronavirus Infections/blood/*epidemiology/*virology[MESH]
  • |Deltacoronavirus/classification/genetics/*isolation & purification/pathogenicity[MESH]
  • |Female[MESH]
  • |Haiti/epidemiology[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Models, Molecular[MESH]
  • |Mutation[MESH]
  • |Phylogeny[MESH]
  • |Swine/*virology[MESH]
  • |Vero Cells[MESH]


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  • suck abstract from ncbi

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