The reactome pathway knowledgebase 2022 #MMPMID34788843
Gillespie M; Jassal B; Stephan R; Milacic M; Rothfels K; Senff-Ribeiro A; Griss J; Sevilla C; Matthews L; Gong C; Deng C; Varusai T; Ragueneau E; Haider Y; May B; Shamovsky V; Weiser J; Brunson T; Sanati N; Beckman L; Shao X; Fabregat A; Sidiropoulos K; Murillo J; Viteri G; Cook J; Shorser S; Bader G; Demir E; Sander C; Haw R; Wu G; Stein L; Hermjakob H; D'Eustachio P
Nucleic Acids Res 2022[Jan]; 50 (D1): D687-D692 PMID34788843show ga
The Reactome Knowledgebase (https://reactome.org), an Elixir core resource, provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary and acquired disease processes. The processes are annotated as an ordered network of molecular transformations in a single consistent data model. Reactome thus functions both as a digital archive of manually curated human biological processes and as a tool for discovering functional relationships in data such as gene expression profiles or somatic mutation catalogs from tumor cells. Recent curation work has expanded our annotations of normal and disease-associated signaling processes and of the drugs that target them, in particular infections caused by the SARS-CoV-1 and SARS-CoV-2 coronaviruses and the host response to infection. New tools support better simultaneous analysis of high-throughput data from multiple sources and the placement of understudied ('dark') proteins from analyzed datasets in the context of Reactome's manually curated pathways.
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Nucleic+Acids+Res 2022 ; 50 (D1): D687-D692
