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10.1371/journal.pone.0259902 http://scihub22266oqcxt.onion/10.1371/journal.pone.0259902 34788328!8598062!34788328     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (11): e0259902 Nephropedia Template TP {{tp|p=34788328|t=2021. Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection |pdf=|usr=}}{{34788328}} gab.com Text Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34788328 #FOAvip BACKGROUND: Coronavirus disease 2019 (COVID-19) is associated with endothelial activation and coagulopathy, which may be related to pre-existing or infection-induced pro-thrombotic autoantibodies such as those targeting angiotensin II type I receptor (AT1R-Ab). METHODS: We compared prevalence and levels of AT1R-Ab in COVID-19 cases with mild or severe disease to age and sex matched negative controls utilizing multivariate logistic and quantile regression adjusted for comorbidities including hypertension, diabetes, and heart disease. RESULTS: There were trends toward increased prevalence (50% vs. 33%, p = 0.1) and level of AT1R-Ab (median 9.8 vs. 6.1 U/mL, p = 0.06) in all cases versus controls. When considered by COVID-19 disease severity, there was a trend toward increased prevalence of AT1R-Ab (55% vs. 31%, p = 0.07), as well as significantly higher AT1R-Ab levels (median 10.7 vs. 5.9 U/mL, p = 0.03) amongst individuals with mild COVID-19 versus matched controls. In contrast, the prevalence (42% vs. 37%, p = 0.9) and level (both medians 6.7 U/mL, p = 0.9) of AT1R-Ab amongst those with severe COVID-19 did not differ from matched controls. CONCLUSIONS: These findings support an association between COVID-19 and AT1R-Ab, emphasizing that vascular pathology may be present in individuals with mild COVID-19 as well as those with severe disease. Twit Text FOAVip Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34788328 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34788328 #FOAvip English Wikipedia <ref>{{Cite pmid|34788328}}</ref> Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection #MMPMID34788328 Jiang Y; Duffy F; Hadlock J; Raappana A; Styrchak S; Beck I; Mast FD; Miller LR; Chour W; Houck J; Armistead B; Duvvuri VR; Yeung W; Haglund M; Wallner J; Wallick JA; Hardy S; Oldroyd A; Ko D; Gervassi A; Murray KM; Kaplan H; Aitchison JD; Heath JR; Sather DN; Goldman JD; Frenkel L; Harrington WE PLoS One 2021[]; 16 (11): e0259902 PMID34788328show ga BACKGROUND: Coronavirus disease 2019 (COVID-19) is associated with endothelial activation and coagulopathy, which may be related to pre-existing or infection-induced pro-thrombotic autoantibodies such as those targeting angiotensin II type I receptor (AT1R-Ab). METHODS: We compared prevalence and levels of AT1R-Ab in COVID-19 cases with mild or severe disease to age and sex matched negative controls utilizing multivariate logistic and quantile regression adjusted for comorbidities including hypertension, diabetes, and heart disease. RESULTS: There were trends toward increased prevalence (50% vs. 33%, p = 0.1) and level of AT1R-Ab (median 9.8 vs. 6.1 U/mL, p = 0.06) in all cases versus controls. When considered by COVID-19 disease severity, there was a trend toward increased prevalence of AT1R-Ab (55% vs. 31%, p = 0.07), as well as significantly higher AT1R-Ab levels (median 10.7 vs. 5.9 U/mL, p = 0.03) amongst individuals with mild COVID-19 versus matched controls. In contrast, the prevalence (42% vs. 37%, p = 0.9) and level (both medians 6.7 U/mL, p = 0.9) of AT1R-Ab amongst those with severe COVID-19 did not differ from matched controls. CONCLUSIONS: These findings support an association between COVID-19 and AT1R-Ab, emphasizing that vascular pathology may be present in individuals with mild COVID-19 as well as those with severe disease. |*COVID-19[MESH] |Adult[MESH] |Graft Rejection[MESH] |Humans[MESH] |Kidney Transplantation[MESH] |Male[MESH] |Middle Aged[MESH]Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infecti(epmc).pdf DeepDyve Pubget Overpricing