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10.26355/eurrev_202111_27123

http://scihub22266oqcxt.onion/10.26355/eurrev_202111_27123
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34787883!ä!34787883

suck abstract from ncbi


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pmid34787883      Eur+Rev+Med+Pharmacol+Sci 2021 ; 25 (21): 6782-6796
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  • Acute severe SARS COVID-19 patients produce pro-resolving lipids mediators and eicosanoids #MMPMID34787883
  • Regidor PA; De La Rosa X; Santos FG; Rizo JM; Gracia Banzo R; Silva RS
  • Eur Rev Med Pharmacol Sci 2021[Nov]; 25 (21): 6782-6796 PMID34787883show ga
  • OBJECTIVE: This study aimed to evaluate the eicosanoid and pro resolutive parameters in SARS COVID-19 patients with the severe acute respiratory syndrome. PATIENTS AND METHODS: Fourteen male patients with an acute respiratory syndrome caused by SARS COVID-19 and four healthy controls were evaluated by measuring the following parameters in plasma: Polyunsaturated fatty acids: EPA, DHA, ARA, and DPA. Specialized Pro-resolving mediators (SPMs) (including monohydroxy-containing precursors 17-HDHA, 18-HEPE, 14-HDHA) resolvins, maresins, protectins, and lipoxins. The eicosanoids group included prostaglandins, thromboxanes, and leukotrienes. RESULTS: Plasma from COVID-19 patients presented higher amounts of pro-inflammatory and pro-thrombotic lipid mediators as compared to healthy subjects (65.7 pg/ml vs. 10.2 pg/ml), including thromboxane (2142.6 pg/ml vs. 10.4 pg/ml), and the ratio between total plasma pro-inflammatory mediators versus total SPM's was 13.2 to 0,4, respectively. CONCLUSIONS: A clear disbalance favoring the pro-inflammatory axis is described, showing the need to perform future clinical interventions in these patients using SPM's or monohydroxylated lipid mediators derivates from fatty acids.
  • |Acute Disease[MESH]
  • |Adult[MESH]
  • |COVID-19/*diagnosis/pathology/virology[MESH]
  • |Case-Control Studies[MESH]
  • |Chromatography, High Pressure Liquid[MESH]
  • |Eicosanoids/*blood[MESH]
  • |Fatty Acids, Unsaturated/blood[MESH]
  • |Humans[MESH]
  • |Inflammation Mediators/*blood[MESH]
  • |Male[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |Severity of Illness Index[MESH]
  • |Tandem Mass Spectrometry[MESH]


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