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10.1172/jci.insight.146701 http://scihub22266oqcxt.onion/10.1172/jci.insight.146701 34784300!8783674!34784300     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2021 ; 6 (24): ä Nephropedia Template TP {{tp|p=34784300|t=2021. PD-1 blockade counteracts post-COVID-19 immune abnormalities and stimulates the anti-SARS-CoV-2 immune response |pdf=|usr=}}{{34784300}} gab.com Text PD-1 blockade counteracts post-COVID-19 immune abnormalities and stimulates the anti-SARS-CoV-2 immune response JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=34784300 #FOAvip A substantial proportion of patients who have recovered from coronavirus disease-2019 (COVID-19) experience COVID-19-related symptoms even months after hospital discharge. We extensively immunologically characterized patients who recovered from COVID-19. In these patients, T cells were exhausted, with increased PD-1+ T cells, as compared with healthy controls. Plasma levels of IL-1beta, IL-1RA, and IL-8, among others, were also increased in patients who recovered from COVID-19. This altered immunophenotype was mirrored by a reduced ex vivo T cell response to both nonspecific and specific stimulation, revealing a dysfunctional status of T cells, including a poor response to SARS-CoV-2 antigens. Altered levels of plasma soluble PD-L1, as well as of PD1 promoter methylation and PD1-targeting miR-15-5p, in CD8+ T cells were also observed, suggesting abnormal function of the PD-1/PD-L1 immune checkpoint axis. Notably, ex vivo blockade of PD-1 nearly normalized the aforementioned immunophenotype and restored T cell function, reverting the observed post-COVID-19 immune abnormalities; indeed, we also noted an increased T cell-mediated response to SARS-CoV-2 peptides. Finally, in a neutralization assay, PD-1 blockade did not alter the ability of T cells to neutralize SARS-CoV-2 spike pseudotyped lentivirus infection. Immune checkpoint blockade ameliorates post-COVID-19 immune abnormalities and stimulates an anti-SARS-CoV-2 immune response. Twit Text FOAVip PD-1 blockade counteracts post-COVID-19 immune abnormalities and stimulates the anti-SARS-CoV-2 immune response ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=34784300 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34784300 #FOAvip English Wikipedia <ref>{{Cite pmid|34784300}}</ref> PD-1 blockade counteracts post-COVID-19 immune abnormalities and stimulates the anti-SARS-CoV-2 immune response #MMPMID34784300 Loretelli C; Abdelsalam A; D'Addio F; Ben Nasr M; Assi E; Usuelli V; Maestroni A; Seelam AJ; Ippolito E; Di Maggio S; Loreggian L; Radovanovic D; Vanetti C; Yang J; El Essawy B; Rossi A; Pastore I; Montefusco L; Lunati ME; Bolla AM; Biasin M; Antinori S; Santus P; Riva A; Zuccotti GV; Galli M; Rusconi S; Fiorina P JCI Insight 2021[Dec]; 6 (24): ä PMID34784300show ga A substantial proportion of patients who have recovered from coronavirus disease-2019 (COVID-19) experience COVID-19-related symptoms even months after hospital discharge. We extensively immunologically characterized patients who recovered from COVID-19. In these patients, T cells were exhausted, with increased PD-1+ T cells, as compared with healthy controls. Plasma levels of IL-1beta, IL-1RA, and IL-8, among others, were also increased in patients who recovered from COVID-19. This altered immunophenotype was mirrored by a reduced ex vivo T cell response to both nonspecific and specific stimulation, revealing a dysfunctional status of T cells, including a poor response to SARS-CoV-2 antigens. Altered levels of plasma soluble PD-L1, as well as of PD1 promoter methylation and PD1-targeting miR-15-5p, in CD8+ T cells were also observed, suggesting abnormal function of the PD-1/PD-L1 immune checkpoint axis. Notably, ex vivo blockade of PD-1 nearly normalized the aforementioned immunophenotype and restored T cell function, reverting the observed post-COVID-19 immune abnormalities; indeed, we also noted an increased T cell-mediated response to SARS-CoV-2 peptides. Finally, in a neutralization assay, PD-1 blockade did not alter the ability of T cells to neutralize SARS-CoV-2 spike pseudotyped lentivirus infection. Immune checkpoint blockade ameliorates post-COVID-19 immune abnormalities and stimulates an anti-SARS-CoV-2 immune response. |B7-H1 Antigen/immunology[MESH] |CD4-Positive T-Lymphocytes/drug effects/immunology[MESH] |CD8-Positive T-Lymphocytes/drug effects/immunology[MESH] |COVID-19/*complications/immunology[MESH] |Case-Control Studies[MESH] |Cytokines/drug effects/*immunology[MESH] |DNA Methylation[MESH] |Female[MESH] |Humans[MESH] |Immune Checkpoint Inhibitors/*pharmacology[MESH] |Immunophenotyping[MESH] |In Vitro Techniques[MESH] |Interleukin 1 Receptor Antagonist Protein/drug effects/immunology[MESH] |Interleukin-1beta/drug effects/immunology[MESH] |Interleukin-8/drug effects/immunology[MESH] |Male[MESH] |MicroRNAs/metabolism[MESH] |Middle Aged[MESH] |Post-Acute COVID-19 Syndrome[MESH] |Programmed Cell Death 1 Receptor/antagonists & inhibitors/*immunology[MESH] |Promoter Regions, Genetic[MESH] |SARS-CoV-2/*immunology[MESH]PD-1 blockade counteracts post-COVID-19 immune abnormalities and stimu(epmc).pdf DeepDyve Pubget Overpricing