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10.1038/s41591-021-01576-3 http://scihub22266oqcxt.onion/10.1038/s41591-021-01576-3 34782790!8799469!34782790     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2022 ; 28 (1): 201-211 Nephropedia Template TP {{tp|p=34782790|t=2022. Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19 |pdf=|usr=}}{{34782790}} gab.com Text Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19 JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=34782790 #FOAvip Although critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus Disease 2019 (COVID-19) ARDS, compared to ARDS from other respiratory pathogens, is unclear. Moreover, mechanisms underlying the beneficial effects of dexamethasone during severe COVID-19 remain elusive. Using single-cell RNA sequencing and plasma proteomics, we discovered that, compared to bacterial ARDS, COVID-19 was associated with expansion of distinct neutrophil states characterized by interferon (IFN) and prostaglandin signaling. Dexamethasone during severe COVID-19 affected circulating neutrophils, altered IFN(active) neutrophils, downregulated interferon-stimulated genes and activated IL-1R2(+) neutrophils. Dexamethasone also expanded immunosuppressive immature neutrophils and remodeled cellular interactions by changing neutrophils from information receivers into information providers. Male patients had higher proportions of IFN(active) neutrophils and preferential steroid-induced immature neutrophil expansion, potentially affecting outcomes. Our single-cell atlas (see 'Data availability' section) defines COVID-19-enriched neutrophil states and molecular mechanisms of dexamethasone action to develop targeted immunotherapies for severe COVID-19. Twit Text FOAVip Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19 ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=34782790 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34782790 #FOAvip English Wikipedia <ref>{{Cite pmid|34782790}}</ref> Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19 #MMPMID34782790 Sinha S; Rosin NL; Arora R; Labit E; Jaffer A; Cao L; Farias R; Nguyen AP; de Almeida LGN; Dufour A; Bromley A; McDonald B; Gillrie MR; Fritzler MJ; Yipp BG; Biernaskie J Nat Med 2022[Jan]; 28 (1): 201-211 PMID34782790show ga Although critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus Disease 2019 (COVID-19) ARDS, compared to ARDS from other respiratory pathogens, is unclear. Moreover, mechanisms underlying the beneficial effects of dexamethasone during severe COVID-19 remain elusive. Using single-cell RNA sequencing and plasma proteomics, we discovered that, compared to bacterial ARDS, COVID-19 was associated with expansion of distinct neutrophil states characterized by interferon (IFN) and prostaglandin signaling. Dexamethasone during severe COVID-19 affected circulating neutrophils, altered IFN(active) neutrophils, downregulated interferon-stimulated genes and activated IL-1R2(+) neutrophils. Dexamethasone also expanded immunosuppressive immature neutrophils and remodeled cellular interactions by changing neutrophils from information receivers into information providers. Male patients had higher proportions of IFN(active) neutrophils and preferential steroid-induced immature neutrophil expansion, potentially affecting outcomes. Our single-cell atlas (see 'Data availability' section) defines COVID-19-enriched neutrophil states and molecular mechanisms of dexamethasone action to develop targeted immunotherapies for severe COVID-19. |Adult[MESH] |Aged[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/complications/genetics/*immunology[MESH] |Cell Communication[MESH] |Chromatography, Liquid[MESH] |Cytokines/*immunology[MESH] |Dexamethasone/*therapeutic use[MESH] |Down-Regulation[MESH] |Female[MESH] |Gene Regulatory Networks[MESH] |Glucocorticoids/*therapeutic use[MESH] |Humans[MESH] |Immunity, Innate/immunology[MESH] |Interferons/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Neutrophils/*immunology/metabolism[MESH] |Pneumonia, Bacterial/complications/drug therapy/genetics/*immunology[MESH] |Prostaglandins/immunology[MESH] |Proteomics[MESH] |RNA-Seq[MESH] |Respiratory Distress Syndrome/drug therapy/etiology/genetics/*immunology[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH] |Sex Factors[MESH] |Single-Cell Analysis[MESH]Dexamethasone modulates immature neutrophils and interferon programmin(epmc).pdf DeepDyve Pubget Overpricing