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10.1038/s41467-021-26910-8 http://scihub22266oqcxt.onion/10.1038/s41467-021-26910-8 34782627!8594428!34782627     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 6602 Nephropedia Template TP {{tp|p=34782627|t=2021. SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis |pdf=|usr=}}{{34782627}} gab.com Text SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34782627 #FOAvip The MHC class I-mediated antigen presentation pathway plays a critical role in antiviral immunity. Here we show that the MHC class I pathway is targeted by SARS-CoV-2. Analysis of the gene expression profile from COVID-19 patients as well as SARS-CoV-2 infected epithelial cell lines reveals that the induction of the MHC class I pathway is inhibited by SARS-CoV-2 infection. We show that NLRC5, an MHC class I transactivator, is suppressed both transcriptionally and functionally by the SARS-CoV-2 ORF6 protein, providing a mechanistic link. SARS-CoV-2 ORF6 hampers type II interferon-mediated STAT1 signaling, resulting in diminished upregulation of NLRC5 and IRF1 gene expression. Moreover, SARS-CoV-2 ORF6 inhibits NLRC5 function via blocking karyopherin complex-dependent nuclear import of NLRC5. Collectively, our study uncovers an immune evasion mechanism of SARS-CoV-2 that targets the function of key MHC class I transcriptional regulators, STAT1-IRF1-NLRC5. Twit Text FOAVip SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34782627 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34782627 #FOAvip English Wikipedia <ref>{{Cite pmid|34782627}}</ref> SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis #MMPMID34782627 Yoo JS; Sasaki M; Cho SX; Kasuga Y; Zhu B; Ouda R; Orba Y; de Figueiredo P; Sawa H; Kobayashi KS Nat Commun 2021[Nov]; 12 (1): 6602 PMID34782627show ga The MHC class I-mediated antigen presentation pathway plays a critical role in antiviral immunity. Here we show that the MHC class I pathway is targeted by SARS-CoV-2. Analysis of the gene expression profile from COVID-19 patients as well as SARS-CoV-2 infected epithelial cell lines reveals that the induction of the MHC class I pathway is inhibited by SARS-CoV-2 infection. We show that NLRC5, an MHC class I transactivator, is suppressed both transcriptionally and functionally by the SARS-CoV-2 ORF6 protein, providing a mechanistic link. SARS-CoV-2 ORF6 hampers type II interferon-mediated STAT1 signaling, resulting in diminished upregulation of NLRC5 and IRF1 gene expression. Moreover, SARS-CoV-2 ORF6 inhibits NLRC5 function via blocking karyopherin complex-dependent nuclear import of NLRC5. Collectively, our study uncovers an immune evasion mechanism of SARS-CoV-2 that targets the function of key MHC class I transcriptional regulators, STAT1-IRF1-NLRC5. |COVID-19/genetics/*immunology/pathology/virology[MESH] |Cell Line[MESH] |Female[MESH] |Gene Expression Regulation[MESH] |Genes, MHC Class I/*immunology[MESH] |Humans[MESH] |Interferon Regulatory Factor-1/*antagonists & inhibitors[MESH] |Intracellular Signaling Peptides and Proteins/*antagonists & inhibitors[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*genetics/isolation & purification[MESH] |STAT1 Transcription Factor/*antagonists & inhibitors[MESH] |Signal Transduction[MESH]SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting (epmc).pdf DeepDyve Pubget Overpricing