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10.1016/j.cellimm.2021.104451 http://scihub22266oqcxt.onion/10.1016/j.cellimm.2021.104451 34781155!8577548!34781155     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Immunol 2022 ; 371 (ä): 104451 Nephropedia Template TP {{tp|p=34781155|t=2022. Roles of the tissue-type plasminogen activator in immune response |pdf=|usr=}}{{34781155}} gab.com Text Roles of the tissue-type plasminogen activator in immune response JO: Cell Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34781155 #FOAvip The COVID-19 pandemic has once again brought to the forefront the existence of a tight link between the coagulation/fibrinolytic system and the immunologic processes. Tissue-type plasminogen activator (tPA) is a serine protease with a key role in fibrinolysis by converting plasminogen into plasmin that can finally degrade fibrin clots. tPA is released in the blood by endothelial cells and hepatocytes but is also produced by various types of immune cells including T cells and monocytes. Beyond its role on hemostasis, tPA is also a potent modulator of inflammation and is involved in the regulation of several inflammatory diseases. Here, after a brief description of tPA structure, we review its new functions in adaptive immunity focusing on T cells and antigen presenting cells. We intend to synthesize the recent knowledge on proteolysis- and receptor-mediated effects of tPA on immune response in physiological and pathological context. Twit Text FOAVip Roles of the tissue-type plasminogen activator in immune response ????Cell Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34781155 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34781155 #FOAvip English Wikipedia <ref>{{Cite pmid|34781155}}</ref> Roles of the tissue-type plasminogen activator in immune response #MMPMID34781155 Seillier C; Helie P; Petit G; Vivien D; Clemente D; Le Mauff B; Docagne F; Toutirais O Cell Immunol 2022[Jan]; 371 (ä): 104451 PMID34781155show ga The COVID-19 pandemic has once again brought to the forefront the existence of a tight link between the coagulation/fibrinolytic system and the immunologic processes. Tissue-type plasminogen activator (tPA) is a serine protease with a key role in fibrinolysis by converting plasminogen into plasmin that can finally degrade fibrin clots. tPA is released in the blood by endothelial cells and hepatocytes but is also produced by various types of immune cells including T cells and monocytes. Beyond its role on hemostasis, tPA is also a potent modulator of inflammation and is involved in the regulation of several inflammatory diseases. Here, after a brief description of tPA structure, we review its new functions in adaptive immunity focusing on T cells and antigen presenting cells. We intend to synthesize the recent knowledge on proteolysis- and receptor-mediated effects of tPA on immune response in physiological and pathological context. |Antigen-Presenting Cells/immunology[MESH] |Blood Coagulation/*immunology[MESH] |COVID-19/epidemiology/*immunology/virology[MESH] |Endothelial Cells/immunology/metabolism[MESH] |Fibrinolysis/*immunology[MESH] |Humans[MESH] |Immunity/*immunology[MESH] |Models, Immunological[MESH] |Pandemics[MESH] |SARS-CoV-2/*immunology/physiology[MESH] |T-Lymphocytes/immunology[MESH]Roles of the tissue-type plasminogen activator in immune response (epmc).pdf DeepDyve Pubget Overpricing