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10.3390/ijms222111388 http://scihub22266oqcxt.onion/10.3390/ijms222111388 34768820!8583705!34768820     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (21): ä Nephropedia Template TP {{tp|p=34768820|t=2021. Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation |pdf=|usr=}}{{34768820}} gab.com Text Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34768820 #FOAvip Disseminated intravascular coagulation (DIC) is a severe condition characterized by the systemic formation of microthrombi complicated with bleeding tendency and organ dysfunction. In the last years, it represents one of the most frequent consequences of coronavirus disease 2019 (COVID-19). The pathogenesis of DIC is complex, with cross-talk between the coagulant and inflammatory pathways. The objective of this study is to investigate the anti-inflammatory action of ultramicronized palmitoylethanolamide (um-PEA) in a lipopolysaccharide (LPS)-induced DIC model in rats. Experimental DIC was induced by continual infusion of LPS (30 mg/kg) for 4 h through the tail vein. Um-PEA (30 mg/kg) was given orally 30 min before and 1 h after the start of intravenous infusion of LPS. Results showed that um-PEA reduced alteration of coagulation markers, as well as proinflammatory cytokine release in plasma and lung samples, induced by LPS infusion. Furthermore, um-PEA also has the effect of preventing the formation of fibrin deposition and lung damage. Moreover, um-PEA was able to reduce the number of mast cells (MCs) and the release of its serine proteases, which are also necessary for SARS-CoV-2 infection. These results suggest that um-PEA could be considered as a potential therapeutic approach in the management of DIC and in clinical implications associated to coagulopathy and lung dysfunction, such as COVID-19. Twit Text FOAVip Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34768820 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34768820 #FOAvip English Wikipedia <ref>{{Cite pmid|34768820}}</ref> Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation #MMPMID34768820 D'Amico R; Monaco F; Siracusa R; Cordaro M; Fusco R; Peritore AF; Gugliandolo E; Crupi R; Cuzzocrea S; Di Paola R; Impellizzeri D; Genovese T Int J Mol Sci 2021[Oct]; 22 (21): ä PMID34768820show ga Disseminated intravascular coagulation (DIC) is a severe condition characterized by the systemic formation of microthrombi complicated with bleeding tendency and organ dysfunction. In the last years, it represents one of the most frequent consequences of coronavirus disease 2019 (COVID-19). The pathogenesis of DIC is complex, with cross-talk between the coagulant and inflammatory pathways. The objective of this study is to investigate the anti-inflammatory action of ultramicronized palmitoylethanolamide (um-PEA) in a lipopolysaccharide (LPS)-induced DIC model in rats. Experimental DIC was induced by continual infusion of LPS (30 mg/kg) for 4 h through the tail vein. Um-PEA (30 mg/kg) was given orally 30 min before and 1 h after the start of intravenous infusion of LPS. Results showed that um-PEA reduced alteration of coagulation markers, as well as proinflammatory cytokine release in plasma and lung samples, induced by LPS infusion. Furthermore, um-PEA also has the effect of preventing the formation of fibrin deposition and lung damage. Moreover, um-PEA was able to reduce the number of mast cells (MCs) and the release of its serine proteases, which are also necessary for SARS-CoV-2 infection. These results suggest that um-PEA could be considered as a potential therapeutic approach in the management of DIC and in clinical implications associated to coagulopathy and lung dysfunction, such as COVID-19. |Amides/chemistry/pharmacology/*therapeutic use[MESH] |Animals[MESH] |Blood Coagulation Disorders/*drug therapy/etiology[MESH] |COVID-19/pathology/virology[MESH] |Cytokines/blood/metabolism[MESH] |Disease Models, Animal[MESH] |Disseminated Intravascular Coagulation/*drug therapy/etiology[MESH] |Ethanolamines/chemistry/pharmacology/*therapeutic use[MESH] |Fibrin Fibrinogen Degradation Products/metabolism[MESH] |Lipopolysaccharides/toxicity[MESH] |Lung/metabolism/pathology[MESH] |Male[MESH] |Mast Cells/cytology/drug effects/metabolism[MESH] |Palmitic Acids/chemistry/pharmacology/*therapeutic use[MESH] |Partial Thromboplastin Time[MESH] |Prothrombin Time[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |SARS-CoV-2/isolation & purification[MESH] |Sepsis/*complications/pathology[MESH]Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Indu(epmc).pdf DeepDyve Pubget Overpricing