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10.1016/j.ajpath.2021.10.009 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2021.10.009 34767812!8577872!34767812     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34767812&cmd=llinks): Failed to open stream: HTTP request failed! 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Progression and Resolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Golden Syrian Hamsters |pdf=|usr=}}{{34767812}} gab.com Text Progression and Resolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Golden Syrian Hamsters JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=34767812 #FOAvip To catalyze severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) research, including development of novel interventive and preventive strategies, the progression of disease was characterized in a robust coronavirus disease 2019 (COVID-19) animal model. In this model, male and female golden Syrian hamsters were inoculated intranasally with SARS-CoV-2 USA-WA1/2020. Groups of inoculated and mock-inoculated uninfected control animals were euthanized at 2, 4, 7, 14, and 28 days after inoculation to track multiple clinical, pathology, virology, and immunology outcomes. SARS-CoV-2-inoculated animals consistently lost body weight during the first week of infection, had higher lung weights at terminal time points, and developed lung consolidation per histopathology and quantitative image analysis measurements. High levels of infectious virus and viral RNA were reliably present in the respiratory tract at days 2 and 4 after inoculation, corresponding with widespread necrosis and inflammation. At day 7, when the presence of infectious virus was rare, interstitial and alveolar macrophage infiltrates and marked reparative epithelial responses (type II hyperplasia) dominated in the lung. These lesions resolved over time, with only residual epithelial repair evident by day 28 after inoculation. The use of quantitative approaches to measure cellular and morphologic alterations in the lung provides valuable outcome measures for developing therapeutic and preventive interventions for COVID-19 using the hamster COVID-19 model. Twit Text FOAVip Progression and Resolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Golden Syrian Hamsters ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=34767812 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34767812 #FOAvip English Wikipedia <ref>{{Cite pmid|34767812}}</ref> Progression and Resolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Golden Syrian Hamsters #MMPMID34767812 Mulka KR; Beck SE; Solis CV; Johanson AL; Queen SE; McCarron ME; Richardson MR; Zhou R; Marinho P; Jedlicka A; Guerrero-Martin S; Shirk EN; Braxton AM; Brockhurst J; Creisher PS; Dhakal S; Brayton CF; Veenhuis RT; Metcalf Pate KA; Karakousis PC; Zahnow CA; Klein SL; Jain SK; Tarwater PM; Pekosz AS; Villano JS; Mankowski JL Am J Pathol 2022[Feb]; 192 (2): 195-207 PMID34767812show ga To catalyze severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) research, including development of novel interventive and preventive strategies, the progression of disease was characterized in a robust coronavirus disease 2019 (COVID-19) animal model. In this model, male and female golden Syrian hamsters were inoculated intranasally with SARS-CoV-2 USA-WA1/2020. Groups of inoculated and mock-inoculated uninfected control animals were euthanized at 2, 4, 7, 14, and 28 days after inoculation to track multiple clinical, pathology, virology, and immunology outcomes. SARS-CoV-2-inoculated animals consistently lost body weight during the first week of infection, had higher lung weights at terminal time points, and developed lung consolidation per histopathology and quantitative image analysis measurements. High levels of infectious virus and viral RNA were reliably present in the respiratory tract at days 2 and 4 after inoculation, corresponding with widespread necrosis and inflammation. At day 7, when the presence of infectious virus was rare, interstitial and alveolar macrophage infiltrates and marked reparative epithelial responses (type II hyperplasia) dominated in the lung. These lesions resolved over time, with only residual epithelial repair evident by day 28 after inoculation. The use of quantitative approaches to measure cellular and morphologic alterations in the lung provides valuable outcome measures for developing therapeutic and preventive interventions for COVID-19 using the hamster COVID-19 model. |Animals[MESH] |COVID-19/*pathology/virology[MESH] |Cricetinae[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Lung/pathology[MESH] |Male[MESH] |Mesocricetus[MESH]Progression and Resolution of Severe Acute Respiratory Syndrome Corona(epmc).pdf DeepDyve Pubget Overpricing