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http://scihub22266oqcxt.onion/ 34765306!8569360!34765306     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Cancer+Res 2021 ; 11 (10): 4994-5005 Nephropedia Template TP {{tp|p=34765306|t=2021. Hyperglycosylated spike of SARS-CoV-2 gamma variant induces breast cancer metastasis |pdf=|usr=}}{{34765306}} gab.com Text Hyperglycosylated spike of SARS-CoV-2 gamma variant induces breast cancer metastasis JO: Am J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=34765306 #FOAvip SARS-CoV-2 exploits the host cellular machinery for virus replication leading to the acute syndrome of coronavirus disease 2019 (COVID-19). Growing evidence suggests SARS-CoV-2 also exacerbates many chronic diseases, including cancers. As mutations on the spike protein (S) emerged as dominant variants that reduce vaccine efficacy, little is known about the relation between SARS-CoV-2 virus variants and cancers. Compared to the SARS-CoV-2 wild-type, the Gamma variant contains two additional NXT/S glycosylation motifs on the S protein. The hyperglycosylated S of Gamma variant is more stable, resulting in more significant epithelial-mesenchymal transition (EMT) potential. SARS-CoV-2 infection promoted NF-kappaB signaling activation and p65 nuclear translocation, inducing Snail expression. Pharmacologic inhibition of NF-kappaB activity by nature food compound, I3C suppressed viral replication and Gamma variant-mediated breast cancer metastasis, indicating that NF-kappaB inhibition can reduce chronic disease in COVID-19 patients. Our study revealed that the Gamma variant of SARS-CoV-2 activates NF-kappaB and, in turn, triggers the pro-survival function for cancer progression. Twit Text FOAVip Hyperglycosylated spike of SARS-CoV-2 gamma variant induces breast cancer metastasis ????Am J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=34765306 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34765306 #FOAvip English Wikipedia <ref>{{Cite pmid|34765306}}</ref> Hyperglycosylated spike of SARS-CoV-2 gamma variant induces breast cancer metastasis #MMPMID34765306 Huang HC; Liao CC; Wang SH; Lee IJ; Lee TA; Hsu JM; Kuo CT; Wang J; Hsieh WC; Chang SJ; Chen SY; Tao MH; Lin YL; Lai YJ; Li CW Am J Cancer Res 2021[]; 11 (10): 4994-5005 PMID34765306show ga SARS-CoV-2 exploits the host cellular machinery for virus replication leading to the acute syndrome of coronavirus disease 2019 (COVID-19). Growing evidence suggests SARS-CoV-2 also exacerbates many chronic diseases, including cancers. As mutations on the spike protein (S) emerged as dominant variants that reduce vaccine efficacy, little is known about the relation between SARS-CoV-2 virus variants and cancers. Compared to the SARS-CoV-2 wild-type, the Gamma variant contains two additional NXT/S glycosylation motifs on the S protein. The hyperglycosylated S of Gamma variant is more stable, resulting in more significant epithelial-mesenchymal transition (EMT) potential. SARS-CoV-2 infection promoted NF-kappaB signaling activation and p65 nuclear translocation, inducing Snail expression. Pharmacologic inhibition of NF-kappaB activity by nature food compound, I3C suppressed viral replication and Gamma variant-mediated breast cancer metastasis, indicating that NF-kappaB inhibition can reduce chronic disease in COVID-19 patients. Our study revealed that the Gamma variant of SARS-CoV-2 activates NF-kappaB and, in turn, triggers the pro-survival function for cancer progression. äHyperglycosylated spike of SARS-CoV-2 gamma variant induces breast can(epmc).pdf DeepDyve Pubget Overpricing