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10.1039/d1sc03526f http://scihub22266oqcxt.onion/10.1039/d1sc03526f 34760193!8565384!34760193     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chem+Sci 2021 ; 12 (42): 14098-14102 Nephropedia Template TP {{tp|p=34760193|t=2021. Allosteric inhibition of SARS-CoV-2 3CL protease by colloidal bismuth subcitrate |pdf=|usr=}}{{34760193}} gab.com Text Allosteric inhibition of SARS-CoV-2 3CL protease by colloidal bismuth subcitrate JO: Chem Sci http://www.kidney.de/pget.php?&tw=1&pmid=34760193 #FOAvip The SARS-CoV-2 3-chymotrypsin-like protease (3CLpro or Mpro) is a key cysteine protease for viral replication and transcription, making it an attractive target for antiviral therapies to combat the COVID-19 disease. Here, we demonstrate that bismuth drug colloidal bismuth subcitrate (CBS) is a potent inhibitor for 3CLpro in vitro and in cellulo. Rather than targeting the cysteine residue at the catalytic site, CBS binds to an allosteric site and results in dissociation of the 3CLpro dimer and proteolytic dysfunction. Our work provides direct evidence that CBS is an allosteric inhibitor of SARS-CoV-2 3CLpro. Twit Text FOAVip Allosteric inhibition of SARS-CoV-2 3CL protease by colloidal bismuth subcitrate ????Chem Sci http://www.kidney.de/pget.php?&tw=1&pmid=34760193 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34760193 #FOAvip English Wikipedia <ref>{{Cite pmid|34760193}}</ref> Allosteric inhibition of SARS-CoV-2 3CL protease by colloidal bismuth subcitrate #MMPMID34760193 Tao X; Zhang L; Du L; Liao R; Cai H; Lu K; Zhao Z; Xie Y; Wang PH; Pan JA; Zhang Y; Li G; Dai J; Mao ZW; Xia W Chem Sci 2021[Nov]; 12 (42): 14098-14102 PMID34760193show ga The SARS-CoV-2 3-chymotrypsin-like protease (3CLpro or Mpro) is a key cysteine protease for viral replication and transcription, making it an attractive target for antiviral therapies to combat the COVID-19 disease. Here, we demonstrate that bismuth drug colloidal bismuth subcitrate (CBS) is a potent inhibitor for 3CLpro in vitro and in cellulo. Rather than targeting the cysteine residue at the catalytic site, CBS binds to an allosteric site and results in dissociation of the 3CLpro dimer and proteolytic dysfunction. Our work provides direct evidence that CBS is an allosteric inhibitor of SARS-CoV-2 3CLpro. äAllosteric inhibition of SARS-CoV-2 3CL protease by colloidal bismuth (epmc).pdf DeepDyve Pubget Overpricing