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10.1016/j.canlet.2021.10.043 http://scihub22266oqcxt.onion/10.1016/j.canlet.2021.10.043 34752845!ä!34752845 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Lett 2022 ; 525 (ä): 179-197 Nephropedia Template TP {{tp|p=34752845|t=2022. Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy |pdf=|usr=}}{{34752845}} gab.com Text Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy JO: Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=34752845 #FOAvip The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitous cation channel possessing kinase activity. TRPM7 mediates a variety of physiological responses by conducting flow of cations such as Ca(2+), Mg(2+), and Zn(2+). Here, we show that the activation of TRPM7 channel stimulated by chemical agonists of TRPM7, Clozapine or Naltriben, inhibited autophagy via mediating Zn(2+) release to the cytosol, presumably from the intracellular Zn(2+)-accumulating vesicles where TRPM7 localizes. Zn(2+) release following the activation of TRPM7 disrupted the fusion between autophagosomes and lysosomes by disturbing the interaction between Sxt17 and VAMP8 which determines fusion status of autophagosomes and lysosomes. Ultimately, the disrupted fusion resulting from stimulation of TRPM7 channels arrested autophagy. Functionally, we demonstrate that the autophagy inhibition mediated by TRPM7 triggered cell death and suppressed metastasis of cancer cells in vitro, more importantly, restricted tumor growth and metastasis in vivo, by evoking apoptosis, cell cycle arrest, and reactive oxygen species (ROS) elevation. These findings represent a strategy for stimulating TRPM7 to combat cancer. Twit Text FOAVip Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy ????Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=34752845 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34752845 #FOAvip English Wikipedia <ref>{{Cite pmid|34752845}}</ref> Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy #MMPMID34752845 Xing Y; Wei X; Wang MM; Liu Y; Sui Z; Wang X; Zhang Y; Fei YH; Jiang Y; Lu C; Zhang P; Chen R; Liu N; Wu M; Ding L; Wang Y; Guo F; Cao JL; Qi J; Wang W Cancer Lett 2022[Jan]; 525 (ä): 179-197 PMID34752845show ga The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitous cation channel possessing kinase activity. TRPM7 mediates a variety of physiological responses by conducting flow of cations such as Ca(2+), Mg(2+), and Zn(2+). Here, we show that the activation of TRPM7 channel stimulated by chemical agonists of TRPM7, Clozapine or Naltriben, inhibited autophagy via mediating Zn(2+) release to the cytosol, presumably from the intracellular Zn(2+)-accumulating vesicles where TRPM7 localizes. Zn(2+) release following the activation of TRPM7 disrupted the fusion between autophagosomes and lysosomes by disturbing the interaction between Sxt17 and VAMP8 which determines fusion status of autophagosomes and lysosomes. Ultimately, the disrupted fusion resulting from stimulation of TRPM7 channels arrested autophagy. Functionally, we demonstrate that the autophagy inhibition mediated by TRPM7 triggered cell death and suppressed metastasis of cancer cells in vitro, more importantly, restricted tumor growth and metastasis in vivo, by evoking apoptosis, cell cycle arrest, and reactive oxygen species (ROS) elevation. These findings represent a strategy for stimulating TRPM7 to combat cancer. |Apoptosis/drug effects[MESH] |Autophagosomes/drug effects[MESH] |Autophagy/drug effects[MESH] |Cell Proliferation/drug effects[MESH] |Clozapine/pharmacology[MESH] |Humans[MESH] |Lysosomes/drug effects[MESH] |Naltrexone/analogs & derivatives/pharmacology[MESH] |Neoplasm Metastasis[MESH] |Neoplasms/*drug therapy/genetics[MESH] |Neoplastic Stem Cells/*drug effects[MESH] |Protein Serine-Threonine Kinases/*genetics[MESH] |R-SNARE Proteins/*genetics[MESH] |Signal Transduction/drug effects[MESH] |TRPM Cation Channels/agonists/*genetics[MESH]Stimulating TRPM7 suppresses cancer cell proliferation and metastasis (epmc).pdf DeepDyve Pubget Overpricing