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10.1097/QCO.0000000000000767 http://scihub22266oqcxt.onion/10.1097/QCO.0000000000000767 34751185!ä!34751185 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34751185&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34751185.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Infect+Dis 2021 ; 34 (6): 718-727 Nephropedia Template TP {{tp|p=34751185|t=2021. Current opinion in management of septic shock due to Gram-negative bacteria |pdf=|usr=}}{{34751185}} gab.com Text Current opinion in management of septic shock due to Gram-negative bacteria JO: Curr Opin Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34751185 #FOAvip PURPOSE OF REVIEW: The COVID-19 pandemic has caused multiple challenges to ICUs, including an increased rate of secondary infections, mostly caused by Gram-negative micro-organisms. Worrying trends of resistance acquisition complicate this picture. We provide a review of the latest evidence to guide management of patients with septic shock because of Gram-negative bacteria. RECENT FINDINGS: New laboratory techniques to detect pathogens and specific resistance patterns from the initial culture are available. Those may assist decreasing the time to adequate antimicrobial therapy and avoid unnecessary broad-spectrum antibiotic overuse. New antimicrobials, including beta-lactam/beta-lactamase inhibitor combinations, such as ceftolozane-tazobactam, imipenem-relebactam or meropenem-vaborbactam and cephalosporins, such as cefiderocol targeted to specific pathogens and resistance patterns are available for use in the clinical setting. Optimization of antibiotic dosing and delivery should follow pharmacokinetic and pharmacodynamic principles and wherever available therapeutic drug monitoring. Management of sepsis has brought capillary refill time back to the spotlight along with more reasoned fluid resuscitation and a moderate approach to timing of dialysis initiation. SUMMARY: Novel rapid diagnostic tests and antimicrobials specifically targeted to Gram-negative pathogens are available and should be used within the principles of antimicrobial stewardship including de-escalation and short duration of antimicrobial therapy. Twit Text FOAVip Current opinion in management of septic shock due to Gram-negative bacteria ????Curr Opin Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34751185 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34751185 #FOAvip English Wikipedia <ref>{{Cite pmid|34751185}}</ref> Current opinion in management of septic shock due to Gram-negative bacteria #MMPMID34751185 Tabah A; Buetti N; Barbier F; Timsit JF Curr Opin Infect Dis 2021[Dec]; 34 (6): 718-727 PMID34751185show ga PURPOSE OF REVIEW: The COVID-19 pandemic has caused multiple challenges to ICUs, including an increased rate of secondary infections, mostly caused by Gram-negative micro-organisms. Worrying trends of resistance acquisition complicate this picture. We provide a review of the latest evidence to guide management of patients with septic shock because of Gram-negative bacteria. RECENT FINDINGS: New laboratory techniques to detect pathogens and specific resistance patterns from the initial culture are available. Those may assist decreasing the time to adequate antimicrobial therapy and avoid unnecessary broad-spectrum antibiotic overuse. New antimicrobials, including beta-lactam/beta-lactamase inhibitor combinations, such as ceftolozane-tazobactam, imipenem-relebactam or meropenem-vaborbactam and cephalosporins, such as cefiderocol targeted to specific pathogens and resistance patterns are available for use in the clinical setting. Optimization of antibiotic dosing and delivery should follow pharmacokinetic and pharmacodynamic principles and wherever available therapeutic drug monitoring. Management of sepsis has brought capillary refill time back to the spotlight along with more reasoned fluid resuscitation and a moderate approach to timing of dialysis initiation. SUMMARY: Novel rapid diagnostic tests and antimicrobials specifically targeted to Gram-negative pathogens are available and should be used within the principles of antimicrobial stewardship including de-escalation and short duration of antimicrobial therapy. |*COVID-19[MESH] |*Gram-Negative Bacterial Infections/diagnosis/drug therapy[MESH] |*Shock, Septic/drug therapy[MESH] |Anti-Bacterial Agents/therapeutic use[MESH] |Cephalosporins[MESH] |Diagnostic Tests, Routine[MESH] |Gram-Negative Bacteria[MESH] |Humans[MESH] |Microbial Sensitivity Tests[MESH] |Pandemics[MESH]Current opinion in management of septic shock due to Gram-negative bac(epmc).pdf DeepDyve Pubget Overpricing