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10.1038/s41598-021-01410-3 http://scihub22266oqcxt.onion/10.1038/s41598-021-01410-3 34750486!8576023!34750486     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34750486&cmd=llinks): Failed to open stream: HTTP request failed! 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Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis |pdf=|usr=}}{{34750486}} gab.com Text Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34750486 #FOAvip Severe acute respiratory syndrome (SARS) is a highly contagious viral respiratory illness. This illness is spurred on by a coronavirus known as SARS-associated coronavirus (SARS-CoV). SARS was first detected in Asia in late February 2003. The genome of this virus is very similar to the SARS-CoV-2. Therefore, the study of SARS-CoV disease and the identification of effective drugs to treat this disease can be new clues for the treatment of SARS-Cov-2. This study aimed to discover novel potential drugs for SARS-CoV disease in order to treating SARS-Cov-2 disease based on a novel systems biology approach. To this end, gene co-expression network analysis was applied. First, the gene co-expression network was reconstructed for 1441 genes, and then two gene modules were discovered as significant modules. Next, a list of miRNAs and transcription factors that target gene co-expression modules' genes were gathered from the valid databases, and two sub-networks formed of transcription factors and miRNAs were established. Afterward, the list of the drugs targeting obtained sub-networks' genes was retrieved from the DGIDb database, and two drug-gene and drug-TF interaction networks were reconstructed. Finally, after conducting different network analyses, we proposed five drugs, including FLUOROURACIL, CISPLATIN, SIROLIMUS, CYCLOPHOSPHAMIDE, and METHYLDOPA, as candidate drugs for SARS-CoV-2 coronavirus treatment. Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus. Twit Text FOAVip Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34750486 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34750486 #FOAvip English Wikipedia <ref>{{Cite pmid|34750486}}</ref> Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis #MMPMID34750486 MotieGhader H; Safavi E; Rezapour A; Amoodizaj FF; Iranifam RA Sci Rep 2021[Nov]; 11 (1): 21872 PMID34750486show ga Severe acute respiratory syndrome (SARS) is a highly contagious viral respiratory illness. This illness is spurred on by a coronavirus known as SARS-associated coronavirus (SARS-CoV). SARS was first detected in Asia in late February 2003. The genome of this virus is very similar to the SARS-CoV-2. Therefore, the study of SARS-CoV disease and the identification of effective drugs to treat this disease can be new clues for the treatment of SARS-Cov-2. This study aimed to discover novel potential drugs for SARS-CoV disease in order to treating SARS-Cov-2 disease based on a novel systems biology approach. To this end, gene co-expression network analysis was applied. First, the gene co-expression network was reconstructed for 1441 genes, and then two gene modules were discovered as significant modules. Next, a list of miRNAs and transcription factors that target gene co-expression modules' genes were gathered from the valid databases, and two sub-networks formed of transcription factors and miRNAs were established. Afterward, the list of the drugs targeting obtained sub-networks' genes was retrieved from the DGIDb database, and two drug-gene and drug-TF interaction networks were reconstructed. Finally, after conducting different network analyses, we proposed five drugs, including FLUOROURACIL, CISPLATIN, SIROLIMUS, CYCLOPHOSPHAMIDE, and METHYLDOPA, as candidate drugs for SARS-CoV-2 coronavirus treatment. Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus. |*COVID-19 Drug Treatment[MESH] |*Drug Repositioning[MESH] |*Gene Expression Profiling[MESH] |*Gene Expression Regulation, Viral[MESH] |*SARS-CoV-2[MESH] |COVID-19/*immunology/*virology[MESH] |Computational Biology[MESH] |Gene Regulatory Networks[MESH] |Genes, Viral[MESH] |Genetic Techniques[MESH] |Humans[MESH] |MicroRNAs/metabolism[MESH] |Oligonucleotide Array Sequence Analysis[MESH] |Systems Biology[MESH]Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-express(epmc).pdf DeepDyve Pubget Overpricing