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COVID-ONE-hi: The One-stop Database for COVID-19-specific Humoral Immunity and Clinical Parameters #MMPMID34748989
Xu Z; Li Y; Lei Q; Huang L; Lai DY; Guo SJ; Jiang HW; Hou H; Zheng YX; Wang XN; Wu J; Ma ML; Zhang B; Chen H; Yu C; Xue JB; Zhang HN; Qi H; Yu S; Lin M; Zhang Y; Lin X; Yao Z; Sheng H; Sun Z; Wang F; Fan X; Tao SC
Genomics Proteomics Bioinformatics 2021[Oct]; 19 (5): 669-678 PMID34748989show ga
Coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2, varies with regard to symptoms and mortality rates among populations. Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19. However, differences in immune responses and clinical features among COVID-19 patients remain largely unknown. Here, we report a database for COVID-19-specific IgG/IgM immune responses and clinical parameters (named COVID-ONE-hi). COVID-ONE-hi is based on the data that contain the IgG/IgM responses to 24 full-length/truncated proteins corresponding to 20 of 28 known SARS-CoV-2 proteins and 199 spike protein peptides against 2360 serum samples collected from 783 COVID-19 patients. In addition, 96 clinical parameters for the 2360 serum samples and basic information for the 783 patients are integrated into the database. Furthermore, COVID-ONE-hi provides a dashboard for defining samples and a one-click analysis pipeline for a single group or paired groups. A set of samples of interest is easily defined by adjusting the scale bars of a variety of parameters. After the "START" button is clicked, one can readily obtain a comprehensive analysis report for further interpretation. COVID-ONE-hi is freely available at www.COVID-ONE.cn.