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10.1172/jci.insight.148749 http://scihub22266oqcxt.onion/10.1172/jci.insight.148749 34747367!8663553!34747367     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2021 ; 6 (21): ä Nephropedia Template TP {{tp|p=34747367|t=2021. Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19 |pdf=|usr=}}{{34747367}} gab.com Text Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19 JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=34747367 #FOAvip COVID-19 is caused by SARS-CoV-2 (SC2) and is more prevalent and severe in elderly and patients with comorbid diseases (CM). Because chitinase 3-like-1 (CHI3L1) is induced during aging and CM, the relationships between CHI3L1 and SC2 were investigated. Here, we demonstrate that CHI3L1 is a potent stimulator of the SC2 receptor angiotensin converting enzyme 2 (ACE2) and viral spike protein priming proteases (SPP), that ACE2 and SPP are induced during aging, and that anti-CHI3L1, kasugamycin, and inhibitors of phosphorylation abrogate these ACE2- and SPP-inductive events. Human studies also demonstrate that the levels of circulating CHI3L1 are increased in the elderly and patients with CM, where they correlate with COVID-19 severity. These studies demonstrate that CHI3L1 is a potent stimulator of ACE2 and SPP, that this induction is a major mechanism contributing to the effects of aging during SC2 infection, and that CHI3L1 co-opts the CHI3L1 axis to augment SC2 infection. CHI3L1 plays a critical role in the pathogenesis of and is an attractive therapeutic target in COVID-19. Twit Text FOAVip Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19 ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=34747367 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34747367 #FOAvip English Wikipedia <ref>{{Cite pmid|34747367}}</ref> Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19 #MMPMID34747367 Kamle S; Ma B; He CH; Akosman B; Zhou Y; Lee CM; El-Deiry WS; Huntington K; Liang O; Machan JT; Kang MJ; Shin HJ; Mizoguchi E; Lee CG; Elias JA JCI Insight 2021[Nov]; 6 (21): ä PMID34747367show ga COVID-19 is caused by SARS-CoV-2 (SC2) and is more prevalent and severe in elderly and patients with comorbid diseases (CM). Because chitinase 3-like-1 (CHI3L1) is induced during aging and CM, the relationships between CHI3L1 and SC2 were investigated. Here, we demonstrate that CHI3L1 is a potent stimulator of the SC2 receptor angiotensin converting enzyme 2 (ACE2) and viral spike protein priming proteases (SPP), that ACE2 and SPP are induced during aging, and that anti-CHI3L1, kasugamycin, and inhibitors of phosphorylation abrogate these ACE2- and SPP-inductive events. Human studies also demonstrate that the levels of circulating CHI3L1 are increased in the elderly and patients with CM, where they correlate with COVID-19 severity. These studies demonstrate that CHI3L1 is a potent stimulator of ACE2 and SPP, that this induction is a major mechanism contributing to the effects of aging during SC2 infection, and that CHI3L1 co-opts the CHI3L1 axis to augment SC2 infection. CHI3L1 plays a critical role in the pathogenesis of and is an attractive therapeutic target in COVID-19. |*Aging/drug effects[MESH] |Aminoglycosides/pharmacology/therapeutic use[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*metabolism[MESH] |Cell Line, Tumor[MESH] |Chitinase-3-Like Protein 1/antagonists & inhibitors/*metabolism[MESH] |HEK293 Cells[MESH] |Humans[MESH]Chitinase 3-like-1 is a therapeutic target that mediates the effects o(epmc).pdf DeepDyve Pubget Overpricing