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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 STAR+Protoc 2021 ; 2 (4): 100873 Nephropedia Template TP
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Computational workflow for functional characterization of COVID-19 through secondary data analysis #MMPMID34746856
Ghandikota S; Sharma M; Jegga AG
STAR Protoc 2021[Dec]; 2 (4): 100873 PMID34746856show ga
Standard transcriptomic analyses cannot fully capture the molecular mechanisms underlying disease pathophysiology and outcomes. We present a computational heterogeneous data integration and mining protocol that combines transcriptional signatures from multiple model systems, protein-protein interactions, single-cell RNA-seq markers, and phenotype-genotype associations to identify functional feature complexes. These feature modules represent a higher order multifeatured machines collectively working toward common pathophysiological goals. We apply this protocol for functional characterization of COVID-19, but it could be applied to many other diseases. For complete details on the use and execution of this protocol, please refer to Ghandikota et al. (2021).