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10.1016/j.xpro.2021.100873

http://scihub22266oqcxt.onion/10.1016/j.xpro.2021.100873
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suck abstract from ncbi


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pmid34746856      STAR+Protoc 2021 ; 2 (4): 100873
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  • Computational workflow for functional characterization of COVID-19 through secondary data analysis #MMPMID34746856
  • Ghandikota S; Sharma M; Jegga AG
  • STAR Protoc 2021[Dec]; 2 (4): 100873 PMID34746856show ga
  • Standard transcriptomic analyses cannot fully capture the molecular mechanisms underlying disease pathophysiology and outcomes. We present a computational heterogeneous data integration and mining protocol that combines transcriptional signatures from multiple model systems, protein-protein interactions, single-cell RNA-seq markers, and phenotype-genotype associations to identify functional feature complexes. These feature modules represent a higher order multifeatured machines collectively working toward common pathophysiological goals. We apply this protocol for functional characterization of COVID-19, but it could be applied to many other diseases. For complete details on the use and execution of this protocol, please refer to Ghandikota et al. (2021).
  • |*Data Analysis[MESH]
  • |*Software[MESH]
  • |*Transcriptome[MESH]
  • |*Workflow[MESH]
  • |COVID-19/*diagnosis/genetics/virology[MESH]
  • |Computational Biology/*methods[MESH]
  • |Humans[MESH]


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