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10.1016/j.ijbiomac.2021.10.112

http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2021.10.112
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34743814!8553634!34743814
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suck abstract from ncbi


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pmid34743814      Int+J+Biol+Macromol 2021 ; 193 (Pt B): 1124-1129
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  • SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate #MMPMID34743814
  • Zheng Y; Zhao J; Li J; Guo Z; Sheng J; Ye X; Jin G; Wang C; Chai W; Yan J; Liu D; Liang X
  • Int J Biol Macromol 2021[Dec]; 193 (Pt B): 1124-1129 PMID34743814show ga
  • Thrombotic complication has been an important symptom in critically ill patients with COVID-19. It has not been clear whether the virus spike (S) protein can directly induce blood coagulation in addition to inflammation. Heparan sulfate (HS)/heparin, a key factor in coagulation process, was found to bind SARS-CoV-2 S protein with high affinity. Herein, we found that the S protein can competitively inhibit the bindings of antithrombin and heparin cofactor II to heparin/HS, causing abnormal increase in thrombin activity. SARS-CoV-2 S protein at a similar concentration (~10 mug/mL) as the viral load in critically ill patients can cause directly blood coagulation and thrombosis in zebrafish model. Furthermore, exogenous heparin/HS can significantly reduce coagulation caused by S protein, pointing to a potential new direction to elucidate the etiology of the virus and provide fundamental support for anticoagulant therapy especially for the COVID-19 critically ill patients.
  • |*Blood Coagulation[MESH]
  • |*Heparitin Sulfate/chemistry/metabolism[MESH]
  • |*SARS-CoV-2/chemistry/metabolism[MESH]
  • |*Spike Glycoprotein, Coronavirus/chemistry/metabolism[MESH]
  • |Animals[MESH]
  • |Humans[MESH]
  • |Mice[MESH]
  • |Protein Binding[MESH]


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