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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Int+J+Biol+Macromol 2021 ; 193 (Pt B): 1124-1129 Nephropedia Template TP
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SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate #MMPMID34743814
Zheng Y; Zhao J; Li J; Guo Z; Sheng J; Ye X; Jin G; Wang C; Chai W; Yan J; Liu D; Liang X
Int J Biol Macromol 2021[Dec]; 193 (Pt B): 1124-1129 PMID34743814show ga
Thrombotic complication has been an important symptom in critically ill patients with COVID-19. It has not been clear whether the virus spike (S) protein can directly induce blood coagulation in addition to inflammation. Heparan sulfate (HS)/heparin, a key factor in coagulation process, was found to bind SARS-CoV-2 S protein with high affinity. Herein, we found that the S protein can competitively inhibit the bindings of antithrombin and heparin cofactor II to heparin/HS, causing abnormal increase in thrombin activity. SARS-CoV-2 S protein at a similar concentration (~10 mug/mL) as the viral load in critically ill patients can cause directly blood coagulation and thrombosis in zebrafish model. Furthermore, exogenous heparin/HS can significantly reduce coagulation caused by S protein, pointing to a potential new direction to elucidate the etiology of the virus and provide fundamental support for anticoagulant therapy especially for the COVID-19 critically ill patients.