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10.1038/s41598-021-01217-2 http://scihub22266oqcxt.onion/10.1038/s41598-021-01217-2 34741071!8571314!34741071     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34741071&cmd=llinks): Failed to open stream: HTTP request failed! 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Diosmectite inhibits the interaction between SARS-CoV-2 and human enterocytes by trapping viral particles, thereby preventing NF-kappaB activation and CXCL10 secretion |pdf=|usr=}}{{34741071}} gab.com Text Diosmectite inhibits the interaction between SARS-CoV-2 and human enterocytes by trapping viral particles, thereby preventing NF-kappaB activation and CXCL10 secretion JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34741071 #FOAvip SARS-CoV-2 enters the intestine by the spike protein binding to angiotensin-converting enzyme 2 (ACE2) receptors in enterocyte apical membranes, leading to diarrhea in some patients. Early treatment of COVID-19-associated diarrhea could relieve symptoms and limit viral spread within the gastrointestinal (GI) tract. Diosmectite, an aluminomagnesium silicate adsorbent clay with antidiarrheal effects, is recommended in some COVID-19 management protocols. In rotavirus models, diosmectite prevents pathogenic effects by binding the virus and its enterotoxin. We tested the trapping and anti-inflammatory properties of diosmectite in a SARS-CoV-2 model. Trapping effects were tested in Caco-2 cells using spike protein receptor-binding domain (RBD) and heat-inactivated SARS-CoV-2 preparations. Trapping was assessed by immunofluorescence, alone or in the presence of cells. The effect of diosmectite on nuclear factor kappa B (NF-kappaB) activation and CXCL10 secretion induced by the spike protein RBD and heat-inactivated SARS-CoV-2 were analyzed by Western blot and ELISA, respectively. Diosmectite bound the spike protein RBD and SARS-CoV-2 preparation, and inhibited interaction of the spike protein RBD with ACE2 receptors on the Caco-2 cell surface. Diosmectite exposure also inhibited NF-kappaB activation and CXCL10 secretion. These data provide direct evidence that diosmectite can bind SARS-CoV-2 components and inhibit downstream inflammation, supporting a mechanistic rationale for consideration of diosmectite as a management option for COVID-19-associated diarrhea. Twit Text FOAVip Diosmectite inhibits the interaction between SARS-CoV-2 and human enterocytes by trapping viral particles, thereby preventing NF-kappaB activation and CXCL10 secretion ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34741071 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34741071 #FOAvip English Wikipedia <ref>{{Cite pmid|34741071}}</ref> Diosmectite inhibits the interaction between SARS-CoV-2 and human enterocytes by trapping viral particles, thereby preventing NF-kappaB activation and CXCL10 secretion #MMPMID34741071 Poeta M; Cioffi V; Buccigrossi V; Nanayakkara M; Baggieri M; Peltrini R; Amoresano A; Magurano F; Guarino A Sci Rep 2021[Nov]; 11 (1): 21725 PMID34741071show ga SARS-CoV-2 enters the intestine by the spike protein binding to angiotensin-converting enzyme 2 (ACE2) receptors in enterocyte apical membranes, leading to diarrhea in some patients. Early treatment of COVID-19-associated diarrhea could relieve symptoms and limit viral spread within the gastrointestinal (GI) tract. Diosmectite, an aluminomagnesium silicate adsorbent clay with antidiarrheal effects, is recommended in some COVID-19 management protocols. In rotavirus models, diosmectite prevents pathogenic effects by binding the virus and its enterotoxin. We tested the trapping and anti-inflammatory properties of diosmectite in a SARS-CoV-2 model. Trapping effects were tested in Caco-2 cells using spike protein receptor-binding domain (RBD) and heat-inactivated SARS-CoV-2 preparations. Trapping was assessed by immunofluorescence, alone or in the presence of cells. The effect of diosmectite on nuclear factor kappa B (NF-kappaB) activation and CXCL10 secretion induced by the spike protein RBD and heat-inactivated SARS-CoV-2 were analyzed by Western blot and ELISA, respectively. Diosmectite bound the spike protein RBD and SARS-CoV-2 preparation, and inhibited interaction of the spike protein RBD with ACE2 receptors on the Caco-2 cell surface. Diosmectite exposure also inhibited NF-kappaB activation and CXCL10 secretion. These data provide direct evidence that diosmectite can bind SARS-CoV-2 components and inhibit downstream inflammation, supporting a mechanistic rationale for consideration of diosmectite as a management option for COVID-19-associated diarrhea. |*COVID-19 Drug Treatment[MESH] |*SARS-CoV-2[MESH] |Adsorption[MESH] |Aluminum Compounds/chemistry[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Anti-Inflammatory Agents[MESH] |Binding Sites[MESH] |Caco-2 Cells[MESH] |Chemokine CXCL10/*metabolism[MESH] |Chromatography, Liquid[MESH] |Clay[MESH] |Diarrhea/etiology/therapy[MESH] |Enterocytes/metabolism[MESH] |Gastroenterology[MESH] |Humans[MESH] |Magnesium Compounds/chemistry[MESH] |Mass Spectrometry[MESH] |Molecular Docking Simulation[MESH] |Molecular Dynamics Simulation[MESH] |NF-kappa B p50 Subunit/*metabolism[MESH] |Protein Binding/drug effects[MESH] |Protein Domains[MESH] |Rotavirus[MESH]Diosmectite inhibits the interaction between SARS-CoV-2 and human ente(epmc).pdf DeepDyve Pubget Overpricing