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10.1016/j.celrep.2021.109959 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.109959 34739850!8531199!34739850     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34739850.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2021 ; 37 (6): 109959 Nephropedia Template TP {{tp|p=34739850|t=2021. Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection |pdf=|usr=}}{{34739850}} gab.com Text Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34739850 #FOAvip Antibody transfer via breastmilk represents an evolutionary strategy to boost immunity in early life. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies have been observed in the breastmilk, the functional quality of these antibodies remains unclear. Here, we apply systems serology to characterize SARS-CoV-2-specific antibodies in maternal serum and breastmilk to compare the functional characteristics of antibodies in these fluids. Distinct SARS-CoV-2-specific antibody responses are observed in the serum and breastmilk of lactating individuals previously infected with SARS-CoV-2, with a more dominant transfer of immunoglobulin A (IgA) and IgM into breastmilk. Although IgGs are present in breastmilk, they are functionally attenuated. We observe preferential transfer of antibodies capable of eliciting neutrophil phagocytosis and neutralization compared to other functions, pointing to selective transfer of certain functional antibodies to breastmilk. These data highlight the preferential transfer of SARS-CoV-2-specific IgA and IgM to breastmilk, accompanied by select IgG subpopulations, positioned to create a non-pathologic but protective barrier against coronavirus disease 2019 (COVID-19). Twit Text FOAVip Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34739850 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34739850 #FOAvip English Wikipedia <ref>{{Cite pmid|34739850}}</ref> Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection #MMPMID34739850 Pullen KM; Atyeo C; Collier AY; Gray KJ; Belfort MB; Lauffenburger DA; Edlow AG; Alter G Cell Rep 2021[Nov]; 37 (6): 109959 PMID34739850show ga Antibody transfer via breastmilk represents an evolutionary strategy to boost immunity in early life. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies have been observed in the breastmilk, the functional quality of these antibodies remains unclear. Here, we apply systems serology to characterize SARS-CoV-2-specific antibodies in maternal serum and breastmilk to compare the functional characteristics of antibodies in these fluids. Distinct SARS-CoV-2-specific antibody responses are observed in the serum and breastmilk of lactating individuals previously infected with SARS-CoV-2, with a more dominant transfer of immunoglobulin A (IgA) and IgM into breastmilk. Although IgGs are present in breastmilk, they are functionally attenuated. We observe preferential transfer of antibodies capable of eliciting neutrophil phagocytosis and neutralization compared to other functions, pointing to selective transfer of certain functional antibodies to breastmilk. These data highlight the preferential transfer of SARS-CoV-2-specific IgA and IgM to breastmilk, accompanied by select IgG subpopulations, positioned to create a non-pathologic but protective barrier against coronavirus disease 2019 (COVID-19). |Antibodies, Viral/*immunology[MESH] |Antibody Formation/immunology[MESH] |COVID-19/*immunology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin Isotypes/immunology[MESH] |Lactation/immunology[MESH] |Milk, Human/*immunology[MESH] |Pregnancy[MESH] |Pregnancy Complications, Infectious/immunology[MESH] |SARS-CoV-2/*immunology[MESH]Selective functional antibody transfer into the breastmilk after SARS-(epmc).pdf DeepDyve Pubget Overpricing