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10.1371/journal.pbio.3001284 http://scihub22266oqcxt.onion/10.1371/journal.pbio.3001284 34735434!8594810!34735434     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Biol 2021 ; 19 (11): e3001284 Nephropedia Template TP {{tp|p=34735434|t=2021. Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge |pdf=|usr=}}{{34735434}} gab.com Text Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge JO: PLoS Biol http://www.kidney.de/pget.php?&tw=1&pmid=34735434 #FOAvip The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a pandemic causing significant damage to public health and the economy. Efforts to understand the mechanisms of Coronavirus Disease 2019 (COVID-19) have been hampered by the lack of robust mouse models. To overcome this barrier, we used a reverse genetic system to generate a mouse-adapted strain of SARS-CoV-2. Incorporating key mutations found in SARS-CoV-2 variants, this model recapitulates critical elements of human infection including viral replication in the lung, immune cell infiltration, and significant in vivo disease. Importantly, mouse adaptation of SARS-CoV-2 does not impair replication in human airway cells and maintains antigenicity similar to human SARS-CoV-2 strains. Coupled with the incorporation of mutations found in variants of concern, CMA3p20 offers several advantages over other mouse-adapted SARS-CoV-2 strains. Using this model, we demonstrate that SARS-CoV-2-infected mice are protected from lethal challenge with the original Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), suggesting immunity from heterologous Coronavirus (CoV) strains. Together, the results highlight the use of this mouse model for further study of SARS-CoV-2 infection and disease. Twit Text FOAVip Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge ????PLoS Biol http://www.kidney.de/pget.php?&tw=1&pmid=34735434 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34735434 #FOAvip English Wikipedia <ref>{{Cite pmid|34735434}}</ref> Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge #MMPMID34735434 Muruato A; Vu MN; Johnson BA; Davis-Gardner ME; Vanderheiden A; Lokugamage K; Schindewolf C; Crocquet-Valdes PA; Langsjoen RM; Plante JA; Plante KS; Weaver SC; Debbink K; Routh AL; Walker D; Suthar MS; Shi PY; Xie X; Menachery VD PLoS Biol 2021[Nov]; 19 (11): e3001284 PMID34735434show ga The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a pandemic causing significant damage to public health and the economy. Efforts to understand the mechanisms of Coronavirus Disease 2019 (COVID-19) have been hampered by the lack of robust mouse models. To overcome this barrier, we used a reverse genetic system to generate a mouse-adapted strain of SARS-CoV-2. Incorporating key mutations found in SARS-CoV-2 variants, this model recapitulates critical elements of human infection including viral replication in the lung, immune cell infiltration, and significant in vivo disease. Importantly, mouse adaptation of SARS-CoV-2 does not impair replication in human airway cells and maintains antigenicity similar to human SARS-CoV-2 strains. Coupled with the incorporation of mutations found in variants of concern, CMA3p20 offers several advantages over other mouse-adapted SARS-CoV-2 strains. Using this model, we demonstrate that SARS-CoV-2-infected mice are protected from lethal challenge with the original Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), suggesting immunity from heterologous Coronavirus (CoV) strains. Together, the results highlight the use of this mouse model for further study of SARS-CoV-2 infection and disease. |Animals[MESH] |COVID-19 Vaccines/*immunology/therapeutic use[MESH] |COVID-19/pathology/*prevention & control[MESH] |Cell Line[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Humans[MESH] |Lung/pathology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Reverse Genetics[MESH] |SARS-CoV-2/*immunology[MESH] |Serial Passage[MESH]Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challen(epmc).pdf DeepDyve Pubget Overpricing