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10.1039/d1cc05508a http://scihub22266oqcxt.onion/10.1039/d1cc05508a 34734602!ä!34734602 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34734602.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Chem+Commun+(Camb) 2021 ; 57 (93): 12476-12479 Nephropedia Template TP {{tp|p=34734602|t=2021. Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2 |pdf=|usr=}}{{34734602}} gab.com Text Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2 JO: Chem Commun (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=34734602 #FOAvip We identified small-molecule enhancers of cellular stress granules by observing molecular crowding of proteins and RNAs in a time-dependent manner. Hit molecules sensitized the IRF3-mediated antiviral mechanism in the presence of poly(I:C) and inhibited the replication of SARS-CoV-2 by inducing stress granule formation. Thus, modulating multimolecular crowding can be a promising strategy against SARS-CoV-2. Twit Text FOAVip Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2 ????Chem Commun (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=34734602 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34734602 #FOAvip English Wikipedia <ref>{{Cite pmid|34734602}}</ref> Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2 #MMPMID34734602 Byun WG; Lee J; Kim S; Park SB Chem Commun (Camb) 2021[Nov]; 57 (93): 12476-12479 PMID34734602show ga We identified small-molecule enhancers of cellular stress granules by observing molecular crowding of proteins and RNAs in a time-dependent manner. Hit molecules sensitized the IRF3-mediated antiviral mechanism in the presence of poly(I:C) and inhibited the replication of SARS-CoV-2 by inducing stress granule formation. Thus, modulating multimolecular crowding can be a promising strategy against SARS-CoV-2. |Animals[MESH] |Antiviral Agents/chemistry/*pharmacology[MESH] |Benzopyrans/chemistry/*pharmacology[MESH] |Cell Line, Tumor[MESH] |Chlorocebus aethiops[MESH] |Cytoplasmic Granules/*drug effects/metabolism[MESH] |Dose-Response Relationship, Drug[MESH] |Drug Combinations[MESH] |Humans[MESH] |Interferon Regulatory Factor-3/metabolism[MESH] |Lopinavir/pharmacology[MESH] |Microbial Sensitivity Tests[MESH] |Molecular Structure[MESH] |Poly I-C/pharmacology[MESH] |Pyrazoles/chemistry/*pharmacology[MESH] |SARS-CoV-2/*drug effects[MESH] |Structure-Activity Relationship[MESH] |Vero Cells[MESH]Harnessing stress granule formation by small molecules to inhibit the (epmc).pdf DeepDyve Pubget Overpricing