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10.1007/978-1-0716-1787-8_7 http://scihub22266oqcxt.onion/10.1007/978-1-0716-1787-8_7 34731469!ä!34731469 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34731469.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Methods+Mol+Biol 2022 ; 2390 (ä): 177-190 Nephropedia Template TP {{tp|p=34731469|t=2022. Network-Driven Drug Discovery |pdf=|usr=}}{{34731469}} gab.com Text Network-Driven Drug Discovery JO: Methods Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=34731469 #FOAvip We describe an approach to early stage drug discovery that explicitly engages with the complexities of human biology. The combined computational and experimental approach is formulated on a conceptual framework in which network biology is used to bridge between individual molecular entities and the cellular phenotype that emerges when those entities interact in a network. Multiple aspects of early stage discovery are addressed including the data-driven elucidation of biological processes implicated in disease, target identification and validation, phenotypic discovery of active molecules and their mechanism of action, and extraction of genetic target support from human population genetics data. Validation is described via summary of a number of discovery projects and details from a project aimed at COVID-19 disease. Twit Text FOAVip Network-Driven Drug Discovery ????Methods Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=34731469 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34731469 #FOAvip English Wikipedia <ref>{{Cite pmid|34731469}}</ref> Network-Driven Drug Discovery #MMPMID34731469 Wray J; Whitmore A Methods Mol Biol 2022[]; 2390 (ä): 177-190 PMID34731469show ga We describe an approach to early stage drug discovery that explicitly engages with the complexities of human biology. The combined computational and experimental approach is formulated on a conceptual framework in which network biology is used to bridge between individual molecular entities and the cellular phenotype that emerges when those entities interact in a network. Multiple aspects of early stage discovery are addressed including the data-driven elucidation of biological processes implicated in disease, target identification and validation, phenotypic discovery of active molecules and their mechanism of action, and extraction of genetic target support from human population genetics data. Validation is described via summary of a number of discovery projects and details from a project aimed at COVID-19 disease. |*COVID-19 Drug Treatment[MESH] |*Drug Discovery[MESH] |*Systems Biology[MESH] |Animals[MESH] |Antiviral Agents/adverse effects/*therapeutic use[MESH] |COVID-19/diagnosis/virology[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Molecular Structure[MESH] |Molecular Targeted Therapy[MESH] |SARS-CoV-2/*drug effects/pathogenicity[MESH]Network-Driven Drug Discovery (epmc).pdf DeepDyve Pubget Overpricing