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10.1172/jci.insight.147170 http://scihub22266oqcxt.onion/10.1172/jci.insight.147170 34731091!8783694!34731091     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34731091&cmd=llinks): Failed to open stream: HTTP request failed! 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SARS-CoV-2 infection mediates differential expression of human endogenous retroviruses and long interspersed nuclear elements |pdf=|usr=}}{{34731091}} gab.com Text SARS-CoV-2 infection mediates differential expression of human endogenous retroviruses and long interspersed nuclear elements JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=34731091 #FOAvip SARS-CoV-2 promotes an imbalanced host response that underlies the development and severity of COVID-19. Infections with viruses are known to modulate transposable elements (TEs), which can exert downstream effects by modulating host gene expression, innate immune sensing, or activities encoded by their protein products. We investigated the impact of SARS-CoV-2 infection on TE expression using RNA-Seq data from cell lines and from primary patient samples. Using a bioinformatics tool, Telescope, we showed that SARS-CoV-2 infection led to upregulation or downregulation of TE transcripts, a subset of which differed from cells infected with SARS, Middle East respiratory syndrome coronavirus (MERS-CoV or MERS), influenza A virus (IAV), respiratory syncytial virus (RSV), and human parainfluenza virus type 3 (HPIV3). Differential expression of key retroelements specifically identified distinct virus families, such as Coronaviridae, with unique retroelement expression subdividing viral species. Analysis of ChIP-Seq data showed that TEs differentially expressed in SARS-CoV-2 infection were enriched for binding sites for transcription factors involved in immune responses and for pioneer transcription factors. In samples from patients with COVID-19, there was significant TE overexpression in bronchoalveolar lavage fluid and downregulation in PBMCs. Thus, although the host gene transcriptome is altered by infection with SARS-CoV-2, the retrotranscriptome may contain the most distinctive features of the cellular response to SARS-CoV-2 infection. Twit Text FOAVip SARS-CoV-2 infection mediates differential expression of human endogenous retroviruses and long interspersed nuclear elements ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=34731091 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34731091 #FOAvip English Wikipedia <ref>{{Cite pmid|34731091}}</ref> SARS-CoV-2 infection mediates differential expression of human endogenous retroviruses and long interspersed nuclear elements #MMPMID34731091 Marston JL; Greenig M; Singh M; Bendall ML; Duarte RRR; Feschotte C; Iniguez LP; Nixon DF JCI Insight 2021[Dec]; 6 (24): ä PMID34731091show ga SARS-CoV-2 promotes an imbalanced host response that underlies the development and severity of COVID-19. Infections with viruses are known to modulate transposable elements (TEs), which can exert downstream effects by modulating host gene expression, innate immune sensing, or activities encoded by their protein products. We investigated the impact of SARS-CoV-2 infection on TE expression using RNA-Seq data from cell lines and from primary patient samples. Using a bioinformatics tool, Telescope, we showed that SARS-CoV-2 infection led to upregulation or downregulation of TE transcripts, a subset of which differed from cells infected with SARS, Middle East respiratory syndrome coronavirus (MERS-CoV or MERS), influenza A virus (IAV), respiratory syncytial virus (RSV), and human parainfluenza virus type 3 (HPIV3). Differential expression of key retroelements specifically identified distinct virus families, such as Coronaviridae, with unique retroelement expression subdividing viral species. Analysis of ChIP-Seq data showed that TEs differentially expressed in SARS-CoV-2 infection were enriched for binding sites for transcription factors involved in immune responses and for pioneer transcription factors. In samples from patients with COVID-19, there was significant TE overexpression in bronchoalveolar lavage fluid and downregulation in PBMCs. Thus, although the host gene transcriptome is altered by infection with SARS-CoV-2, the retrotranscriptome may contain the most distinctive features of the cellular response to SARS-CoV-2 infection. |A549 Cells[MESH] |COVID-19/*genetics[MESH] |Cell Line[MESH] |Chromatin Immunoprecipitation Sequencing[MESH] |Computational Biology[MESH] |Coronavirus Infections/genetics[MESH] |DNA Transposable Elements/genetics[MESH] |Down-Regulation[MESH] |Endogenous Retroviruses/*genetics[MESH] |Host Microbial Interactions/genetics[MESH] |Humans[MESH] |In Vitro Techniques[MESH] |Influenza A virus[MESH] |Influenza, Human/genetics[MESH] |Long Interspersed Nucleotide Elements/*genetics[MESH] |Middle East Respiratory Syndrome Coronavirus[MESH] |Parainfluenza Virus 3, Human[MESH] |RNA-Seq[MESH] |Respiratory Syncytial Virus Infections/genetics[MESH] |Respiratory Syncytial Viruses[MESH] |Respirovirus Infections/genetics[MESH] |Retroelements/genetics[MESH] |SARS-CoV-2[MESH] |Severe Acute Respiratory Syndrome/genetics[MESH] |Severe acute respiratory syndrome-related coronavirus[MESH] |Transcriptome[MESH]SARS-CoV-2 infection mediates differential expression of human endogen(epmc).pdf DeepDyve Pubget Overpricing