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10.1038/s41598-021-01054-3 http://scihub22266oqcxt.onion/10.1038/s41598-021-01054-3 34728736!8563742!34728736     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 21462 Nephropedia Template TP {{tp|p=34728736|t=2021. Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction |pdf=|usr=}}{{34728736}} gab.com Text Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34728736 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease-19 (COVID-19). More than 143 million cases of COVID-19 have been reported to date, with the global death rate at 2.13%. Currently, there are no licensed therapeutics for controlling SARS-CoV-2 infection. The antiviral effects of heme oxygenase-1 (HO-1), a cytoprotective enzyme that inhibits the inflammatory response and reduces oxidative stress, have been investigated in several viral infections. To confirm whether HO-1 suppresses SARS-CoV-2 infection, we assessed the antiviral activity of hemin, an effective and safe HO-1 inducer, in SARS-CoV-2 infection. We found that treatment with hemin efficiently suppressed SARS-CoV-2 replication (selectivity index: 249.7012). Besides, the transient expression of HO-1 using an expression vector also suppressed the growth of the virus in cells. Free iron and biliverdin, which are metabolic byproducts of heme catalysis by HO-1, also suppressed the viral infection. Additionally, hemin indirectly increased the expression of interferon-stimulated proteins known to restrict SARS-CoV-2 replication. Overall, the findings suggested that HO-1, induced by hemin, effectively suppressed SARS-CoV-2 in vitro. Therefore, HO-1 could be potential therapeutic candidate for COVID-19. Twit Text FOAVip Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34728736 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34728736 #FOAvip English Wikipedia <ref>{{Cite pmid|34728736}}</ref> Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction #MMPMID34728736 Kim DH; Ahn HS; Go HJ; Kim DY; Kim JH; Lee JB; Park SY; Song CS; Lee SW; Ha SD; Choi C; Choi IS Sci Rep 2021[Nov]; 11 (1): 21462 PMID34728736show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease-19 (COVID-19). More than 143 million cases of COVID-19 have been reported to date, with the global death rate at 2.13%. Currently, there are no licensed therapeutics for controlling SARS-CoV-2 infection. The antiviral effects of heme oxygenase-1 (HO-1), a cytoprotective enzyme that inhibits the inflammatory response and reduces oxidative stress, have been investigated in several viral infections. To confirm whether HO-1 suppresses SARS-CoV-2 infection, we assessed the antiviral activity of hemin, an effective and safe HO-1 inducer, in SARS-CoV-2 infection. We found that treatment with hemin efficiently suppressed SARS-CoV-2 replication (selectivity index: 249.7012). Besides, the transient expression of HO-1 using an expression vector also suppressed the growth of the virus in cells. Free iron and biliverdin, which are metabolic byproducts of heme catalysis by HO-1, also suppressed the viral infection. Additionally, hemin indirectly increased the expression of interferon-stimulated proteins known to restrict SARS-CoV-2 replication. Overall, the findings suggested that HO-1, induced by hemin, effectively suppressed SARS-CoV-2 in vitro. Therefore, HO-1 could be potential therapeutic candidate for COVID-19. |*COVID-19 Drug Treatment[MESH] |Animals[MESH] |Antiviral Agents/chemistry/pharmacology/*therapeutic use[MESH] |COVID-19/virology[MESH] |Cell Survival/drug effects[MESH] |Chlorocebus aethiops[MESH] |Heme Oxygenase-1/antagonists & inhibitors/genetics/*metabolism[MESH] |Hemin/chemistry/pharmacology/*therapeutic use[MESH] |Humans[MESH] |RNA Interference[MESH] |RNA, Small Interfering/metabolism[MESH] |RNA, Viral/metabolism[MESH] |SARS-CoV-2/genetics/isolation & purification/physiology[MESH] |Up-Regulation/drug effects[MESH] |Vero Cells[MESH]Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 (epmc).pdf DeepDyve Pubget Overpricing