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10.1016/j.smim.2021.101508 http://scihub22266oqcxt.onion/10.1016/j.smim.2021.101508 34728121!8547971!34728121     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Semin+Immunol 2021 ; 55 (ä): 101508 Nephropedia Template TP {{tp|p=34728121|t=2021. Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion |pdf=|usr=}}{{34728121}} gab.com Text Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion JO: Semin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34728121 #FOAvip One and half year following the occurrence of COVID-19 pandemic, significant efforts from laboratories all over the world generated a huge amount of data describing the prototypical features of immunity in the course of SARS-CoV-2 infection. In this Review, we rationalize and organize the main observations, trying to define a "core" signature of immunity in COVID-19. We identified six hallmarks describing the main alterations occurring in the early infection phase and in the course of the disease, which predispose to severe illness. The six hallmarks are dysregulated type I IFN activity, hyperinflammation, lymphopenia, lymphocyte impairment, dysregulated myeloid response, and heterogeneous adaptive immunity to SARS-CoV-2. Dysregulation and exhaustion came out as the trait d'union, connecting abnormalities affecting both innate and adaptive immunity, humoral and cellular responses. Twit Text FOAVip Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion ????Semin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34728121 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34728121 #FOAvip English Wikipedia <ref>{{Cite pmid|34728121}}</ref> Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion #MMPMID34728121 Mazzoni A; Salvati L; Maggi L; Annunziato F; Cosmi L Semin Immunol 2021[Jun]; 55 (ä): 101508 PMID34728121show ga One and half year following the occurrence of COVID-19 pandemic, significant efforts from laboratories all over the world generated a huge amount of data describing the prototypical features of immunity in the course of SARS-CoV-2 infection. In this Review, we rationalize and organize the main observations, trying to define a "core" signature of immunity in COVID-19. We identified six hallmarks describing the main alterations occurring in the early infection phase and in the course of the disease, which predispose to severe illness. The six hallmarks are dysregulated type I IFN activity, hyperinflammation, lymphopenia, lymphocyte impairment, dysregulated myeloid response, and heterogeneous adaptive immunity to SARS-CoV-2. Dysregulation and exhaustion came out as the trait d'union, connecting abnormalities affecting both innate and adaptive immunity, humoral and cellular responses. |*COVID-19[MESH] |Adaptive Immunity[MESH] |Humans[MESH] |Pandemics[MESH]Hallmarks of immune response in COVID-19: Exploring dysregulation and (epmc).pdf DeepDyve Pubget Overpricing