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10.1140/epjp/s13360-021-01960-5

http://scihub22266oqcxt.onion/10.1140/epjp/s13360-021-01960-5
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34725629!8551353!34725629
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suck abstract from ncbi

pmid34725629      Eur+Phys+J+Plus 2021 ; 136 (10): 1080
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  • DNA Mutations via Chern-Simons Currents #MMPMID34725629
  • Bajardi F; Altucci L; Benedetti R; Capozziello S; Sorbo MRD; Franci G; Altucci C
  • Eur Phys J Plus 2021[]; 136 (10): 1080 PMID34725629show ga
  • We test the validity of a possible schematization of DNA structure and dynamics based on the Chern-Simons theory, that is a topological field theory mostly considered in the context of effective gravity theories. By means of the expectation value of the Wilson Loop, derived from this analogue gravity approach, we find the point-like curvature of genomic strings in KRAS human gene and COVID-19 sequences, correlating this curvature with the genetic mutations. The point-like curvature profile, obtained by means of the Chern-Simons currents, can be used to infer the position of the given mutations within the genetic string. Generally, mutations take place in the highest Chern-Simons current gradient locations and subsequent mutated sequences appear to have a smoother curvature than the initial ones, in agreement with a free energy minimization argument.
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