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10.1016/j.isci.2021.103325 http://scihub22266oqcxt.onion/10.1016/j.isci.2021.103325 34723157!8536484!34723157     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34723157&cmd=llinks): Failed to open stream: HTTP request failed! 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Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19 |pdf=|usr=}}{{34723157}} gab.com Text Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19 JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=34723157 #FOAvip In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory and may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular, and transcriptomic imprints of pathological responses linked to autoreactive B cells at single-cell resolution. We show that excessive plasmablast expansions are prognostically adverse and correlate with autoantibody production but do not hinder the formation of neutralizing antibodies. Although plasmablasts followed interleukin-4 (IL-4) and BAFF-driven developmental trajectories, were polyclonal, and not enriched in autoreactive B cells, we identified two memory populations (CD80(+)/ISG15(+) and CD11c(+)/SOX5(+)/T-bet(+/-)) with immunogenetic and transcriptional signs of autoreactivity that may be the cellular source of autoantibodies in COVID-19 and that may persist beyond recovery. Immunomodulatory interventions discouraging such adverse responses may be useful in selected patients to shift the balance from autoreactivity toward long-term memory. Twit Text FOAVip Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19 ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=34723157 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34723157 #FOAvip English Wikipedia <ref>{{Cite pmid|34723157}}</ref> Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19 #MMPMID34723157 Schultheiss C; Paschold L; Willscher E; Simnica D; Wostemeier A; Muscate F; Wass M; Eisenmann S; Dutzmann J; Keysser G; Gagliani N; Binder M iScience 2021[Nov]; 24 (11): 103325 PMID34723157show ga In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory and may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular, and transcriptomic imprints of pathological responses linked to autoreactive B cells at single-cell resolution. We show that excessive plasmablast expansions are prognostically adverse and correlate with autoantibody production but do not hinder the formation of neutralizing antibodies. Although plasmablasts followed interleukin-4 (IL-4) and BAFF-driven developmental trajectories, were polyclonal, and not enriched in autoreactive B cells, we identified two memory populations (CD80(+)/ISG15(+) and CD11c(+)/SOX5(+)/T-bet(+/-)) with immunogenetic and transcriptional signs of autoreactivity that may be the cellular source of autoantibodies in COVID-19 and that may persist beyond recovery. Immunomodulatory interventions discouraging such adverse responses may be useful in selected patients to shift the balance from autoreactivity toward long-term memory. äMaturation trajectories and transcriptional landscape of plasmablasts (epmc).pdf DeepDyve Pubget Overpricing