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10.1002/advs.202102181 http://scihub22266oqcxt.onion/10.1002/advs.202102181 34716683!8646600!34716683     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Sci+(Weinh) 2022 ; 9 (1): e2102181 Nephropedia Template TP {{tp|p=34716683|t=2022. Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago |pdf=|usr=}}{{34716683}} gab.com Text Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago JO: Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=34716683 #FOAvip Combinatorial antibody libraries not only effectively reduce antibody discovery to a numbers game, but enable documentation of the history of antibody responses in an individual. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has prompted a wider application of this technology to meet the public health challenge of pandemic threats in the modern era. Herein, a combinatorial human antibody library constructed 20 years before the coronavirus disease 2019 (COVID-19) pandemic is used to discover three highly potent antibodies that selectively bind SARS-CoV-2 spike protein and neutralize authentic SARS-CoV-2 virus. Compared to neutralizing antibodies from COVID-19 patients with generally low somatic hypermutation (SHM), these three antibodies contain over 13-22 SHMs, many of which are involved in specific interactions in their crystal structures with SARS-CoV-2 spike receptor binding domain. The identification of these somatically mutated antibodies in a pre-pandemic library raises intriguing questions about the origin and evolution of these antibodies with respect to their reactivity with SARS-CoV-2. Twit Text FOAVip Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago ????Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=34716683 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34716683 #FOAvip English Wikipedia <ref>{{Cite pmid|34716683}}</ref> Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago #MMPMID34716683 Qiang M; Ma P; Li Y; Liu H; Harding A; Min C; Wang F; Liu L; Yuan M; Ji Q; Tao P; Shi X; Li Z; Li T; Wang X; Zhang Y; Wu NC; Lee CD; Zhu X; Gilbert-Jaramillo J; Zhang C; Saxena A; Huang X; Wang H; James W; Dwek RA; Wilson IA; Yang G; Lerner RA Adv Sci (Weinh) 2022[Jan]; 9 (1): e2102181 PMID34716683show ga Combinatorial antibody libraries not only effectively reduce antibody discovery to a numbers game, but enable documentation of the history of antibody responses in an individual. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has prompted a wider application of this technology to meet the public health challenge of pandemic threats in the modern era. Herein, a combinatorial human antibody library constructed 20 years before the coronavirus disease 2019 (COVID-19) pandemic is used to discover three highly potent antibodies that selectively bind SARS-CoV-2 spike protein and neutralize authentic SARS-CoV-2 virus. Compared to neutralizing antibodies from COVID-19 patients with generally low somatic hypermutation (SHM), these three antibodies contain over 13-22 SHMs, many of which are involved in specific interactions in their crystal structures with SARS-CoV-2 spike receptor binding domain. The identification of these somatically mutated antibodies in a pre-pandemic library raises intriguing questions about the origin and evolution of these antibodies with respect to their reactivity with SARS-CoV-2. |Angiotensin-Converting Enzyme 2/genetics/*metabolism[MESH] |Animals[MESH] |Antibodies, Neutralizing/genetics/*immunology/metabolism/pharmacology[MESH] |Antibodies, Viral/immunology[MESH] |Binding Sites[MESH] |Binding, Competitive[MESH] |Cell Surface Display Techniques[MESH] |Chlorocebus aethiops[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Peptide Library[MESH] |SARS-CoV-2/drug effects/*immunology[MESH] |Somatic Hypermutation, Immunoglobulin[MESH] |Spike Glycoprotein, Coronavirus/genetics/immunology/*metabolism[MESH]Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody L(epmc).pdf DeepDyve Pubget Overpricing