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10.1038/s41598-021-00851-0 http://scihub22266oqcxt.onion/10.1038/s41598-021-00851-0 34716394!8556282!34716394     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 21297 Nephropedia Template TP {{tp|p=34716394|t=2021. Dysbiosis and structural disruption of the respiratory microbiota in COVID-19 patients with severe and fatal outcomes |pdf=|usr=}}{{34716394}} gab.com Text Dysbiosis and structural disruption of the respiratory microbiota in COVID-19 patients with severe and fatal outcomes JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34716394 #FOAvip The COVID-19 outbreak has caused over three million deaths worldwide. Understanding the pathology of the disease and the factors that drive severe and fatal clinical outcomes is of special relevance. Studying the role of the respiratory microbiota in COVID-19 is especially important as the respiratory microbiota is known to interact with the host immune system, contributing to clinical outcomes in chronic and acute respiratory diseases. Here, we characterized the microbiota in the respiratory tract of patients with mild, severe, or fatal COVID-19, and compared it to healthy controls and patients with non-COVID-19-pneumonia. We comparatively studied the microbial composition, diversity, and microbiota structure between the study groups and correlated the results with clinical data. We found differences in the microbial composition for COVID-19 patients, healthy controls, and non-COVID-19 pneumonia controls. In particular, we detected a high number of potentially opportunistic pathogens associated with severe and fatal levels of the disease. Also, we found higher levels of dysbiosis in the respiratory microbiota of patients with COVID-19 compared to the healthy controls. In addition, we detected differences in diversity structure between the microbiota of patients with mild, severe, and fatal COVID-19, as well as the presence of specific bacteria that correlated with clinical variables associated with increased risk of mortality. In summary, our results demonstrate that increased dysbiosis of the respiratory tract microbiota in patients with COVID-19 along with a continuous loss of microbial complexity structure found in mild to fatal COVID-19 cases may potentially alter clinical outcomes in patients. Taken together, our findings identify the respiratory microbiota as a factor potentially associated with the severity of COVID-19. Twit Text FOAVip Dysbiosis and structural disruption of the respiratory microbiota in COVID-19 patients with severe and fatal outcomes ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34716394 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34716394 #FOAvip English Wikipedia <ref>{{Cite pmid|34716394}}</ref> Dysbiosis and structural disruption of the respiratory microbiota in COVID-19 patients with severe and fatal outcomes #MMPMID34716394 Hernandez-Teran A; Mejia-Nepomuceno F; Herrera MT; Barreto O; Garcia E; Castillejos M; Boukadida C; Matias-Florentino M; Rincon-Rubio A; Avila-Rios S; Mujica-Sanchez M; Serna-Munoz R; Becerril-Vargas E; Guadarrama-Perez C; Ahumada-Topete VH; Rodriguez-Llamazares S; Martinez-Orozco JA; Salas-Hernandez J; Perez-Padilla R; Vazquez-Perez JA Sci Rep 2021[Oct]; 11 (1): 21297 PMID34716394show ga The COVID-19 outbreak has caused over three million deaths worldwide. Understanding the pathology of the disease and the factors that drive severe and fatal clinical outcomes is of special relevance. Studying the role of the respiratory microbiota in COVID-19 is especially important as the respiratory microbiota is known to interact with the host immune system, contributing to clinical outcomes in chronic and acute respiratory diseases. Here, we characterized the microbiota in the respiratory tract of patients with mild, severe, or fatal COVID-19, and compared it to healthy controls and patients with non-COVID-19-pneumonia. We comparatively studied the microbial composition, diversity, and microbiota structure between the study groups and correlated the results with clinical data. We found differences in the microbial composition for COVID-19 patients, healthy controls, and non-COVID-19 pneumonia controls. In particular, we detected a high number of potentially opportunistic pathogens associated with severe and fatal levels of the disease. Also, we found higher levels of dysbiosis in the respiratory microbiota of patients with COVID-19 compared to the healthy controls. In addition, we detected differences in diversity structure between the microbiota of patients with mild, severe, and fatal COVID-19, as well as the presence of specific bacteria that correlated with clinical variables associated with increased risk of mortality. In summary, our results demonstrate that increased dysbiosis of the respiratory tract microbiota in patients with COVID-19 along with a continuous loss of microbial complexity structure found in mild to fatal COVID-19 cases may potentially alter clinical outcomes in patients. Taken together, our findings identify the respiratory microbiota as a factor potentially associated with the severity of COVID-19. |*Severity of Illness Index[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Bacteria/*genetics[MESH] |COVID-19/*microbiology/*mortality/pathology[MESH] |Case-Control Studies[MESH] |Dysbiosis/*microbiology[MESH] |Female[MESH] |Humans[MESH] |Kaplan-Meier Estimate[MESH] |Male[MESH] |Microbiota/*genetics[MESH] |Middle Aged[MESH] |Phylogeny[MESH] |RNA, Ribosomal, 16S/genetics[MESH] |Respiratory System/*microbiology[MESH] |SARS-CoV-2/*genetics[MESH]Dysbiosis and structural disruption of the respiratory microbiota in C(epmc).pdf DeepDyve Pubget Overpricing