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10.1038/s41467-021-26500-8 http://scihub22266oqcxt.onion/10.1038/s41467-021-26500-8 34716338!8556379!34716338     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34716338.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2021 ; 12 (1): 6243 Nephropedia Template TP {{tp|p=34716338|t=2021. Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host |pdf=|usr=}}{{34716338}} gab.com Text Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34716338 #FOAvip Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that the respiratory microbiome may be playing a role in disease progression, yet current studies report contradictory results. Here, we examine potential confounders in COVID-19 respiratory microbiome studies by analyzing the upper (n = 58) and lower (n = 35) respiratory tract microbiome in well-phenotyped COVID-19 patients and controls combining microbiome sequencing, viral load determination, and immunoprofiling. We find that time in the intensive care unit and type of oxygen support, as well as associated treatments such as antibiotic usage, explain the most variation within the upper respiratory tract microbiome, while SARS-CoV-2 viral load has a reduced impact. Specifically, mechanical ventilation is linked to altered community structure and significant shifts in oral taxa previously associated with COVID-19. Single-cell transcriptomics of the lower respiratory tract of COVID-19 patients identifies specific oral bacteria in physical association with proinflammatory immune cells, which show higher levels of inflammatory markers. Overall, our findings suggest confounders are driving contradictory results in current COVID-19 microbiome studies and careful attention needs to be paid to ICU stay and type of oxygen support, as bacteria favored in these conditions may contribute to the inflammatory phenotypes observed in severe COVID-19 patients. Twit Text FOAVip Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34716338 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34716338 #FOAvip English Wikipedia <ref>{{Cite pmid|34716338}}</ref> Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host #MMPMID34716338 Llorens-Rico V; Gregory AC; Van Weyenbergh J; Jansen S; Van Buyten T; Qian J; Braz M; Menezes SM; Van Mol P; Vanderbeke L; Dooms C; Gunst J; Hermans G; Meersseman P; Wauters E; Neyts J; Lambrechts D; Wauters J; Raes J Nat Commun 2021[Oct]; 12 (1): 6243 PMID34716338show ga Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that the respiratory microbiome may be playing a role in disease progression, yet current studies report contradictory results. Here, we examine potential confounders in COVID-19 respiratory microbiome studies by analyzing the upper (n = 58) and lower (n = 35) respiratory tract microbiome in well-phenotyped COVID-19 patients and controls combining microbiome sequencing, viral load determination, and immunoprofiling. We find that time in the intensive care unit and type of oxygen support, as well as associated treatments such as antibiotic usage, explain the most variation within the upper respiratory tract microbiome, while SARS-CoV-2 viral load has a reduced impact. Specifically, mechanical ventilation is linked to altered community structure and significant shifts in oral taxa previously associated with COVID-19. Single-cell transcriptomics of the lower respiratory tract of COVID-19 patients identifies specific oral bacteria in physical association with proinflammatory immune cells, which show higher levels of inflammatory markers. Overall, our findings suggest confounders are driving contradictory results in current COVID-19 microbiome studies and careful attention needs to be paid to ICU stay and type of oxygen support, as bacteria favored in these conditions may contribute to the inflammatory phenotypes observed in severe COVID-19 patients. |COVID-19/*microbiology[MESH] |Gastrointestinal Microbiome/genetics/physiology[MESH] |Humans[MESH] |Microbiota/physiology[MESH] |SARS-CoV-2/pathogenicity[MESH]Clinical practices underlie COVID-19 patient respiratory microbiome co(epmc).pdf DeepDyve Pubget Overpricing