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10.1007/s11239-021-02597-y

http://scihub22266oqcxt.onion/10.1007/s11239-021-02597-y
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suck abstract from ncbi


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pmid34709533      J+Thromb+Thrombolysis 2022 ; 53 (3): 581-585
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  • The role of lipoprotein(a) in coronavirus disease 2019 (COVID-19) with relation to development of severe acute kidney injury #MMPMID34709533
  • Lippi G; Szergyuk I; de Oliveira MHS; Benoit SW; Benoit JL; Favaloro EJ; Henry BM
  • J Thromb Thrombolysis 2022[Apr]; 53 (3): 581-585 PMID34709533show ga
  • Lipoprotein(a) (Lp(a)) is a prothrombotic and anti-fibrinolytic lipoprotein, whose role has not been clearly defined in the pathogenesis of coronavirus disease 2019 (COVID-19). In this prospective observational study, serum Lp(a) as well as outcomes were measured in 50 COVID-19 patients and 30 matched sick controls. Lp(a) was also assessed for correlation with a wide panel of biomarkers. Serum Lp(a) did not significantly differ between COVID-19 patients and sick controls, though its concentration was found to be significantly associated with severity of COVID-19 illness, including acute kidney failure stage (r = 0.380, p = 0.007), admission disease severity (r = 0.355, p = 0.013), and peak severity (r = 0.314; p = 0.03). Lp(a) was also positively correlated with interleukin (IL)-8 (r = 0.308; p = 0.037), fibrinogen (r = 0.344; p = 0.032) and creatinine (r = 0.327; p = 0.027), and negatively correlated with ADAMTS13 activity/VWF:Ag (r = - 0.335; p = 0.021); but not with IL-6 (r = 0.241; p = 0.106). These results would hence suggest that adverse outcomes in patients with COVID-19 may be aggravated by a genetically determined hyper-Lp(a) state rather than any inflammation induced elevations.
  • |*Acute Kidney Injury/etiology[MESH]
  • |*COVID-19/complications[MESH]
  • |Biomarkers[MESH]
  • |Humans[MESH]
  • |Lipoprotein(a)[MESH]


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