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10.1016/j.isci.2021.103191 http://scihub22266oqcxt.onion/10.1016/j.isci.2021.103191 34703991!8521184!34703991     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2021 ; 24 (10): 103191 Nephropedia Template TP {{tp|p=34703991|t=2021. MR-PheWAS for the causal effects of serum magnesium on multiple disease outcomes in Caucasian descent |pdf=|usr=}}{{34703991}} gab.com Text MR-PheWAS for the causal effects of serum magnesium on multiple disease outcomes in Caucasian descent JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=34703991 #FOAvip Magnesium is integral to many physiological processes, whereas variations in its levels, even within the normal range, can have critical implications for health. To explore the broad clinical effects of varying serum magnesium levels, we performed a two-sample Mendelian randomization and phenome-wide association study (MR-PheWAS) in the UK Biobank cohort. In total, MR-PheWAS analysis implicated a causal role of serum magnesium levels in five disease groups and six disease outcomes. In addition, our study indicated the gender-specific effects of nine disease groups/outcomes in MR estimated effects. The protein-protein interaction network demonstrated an interaction between the serum magnesium-associated gene DCDC1 and the cataract- associated gene PAX6. The present study verified several previously reported disease outcomes and identified novel potential disease outcomes for serum magnesium levels. The DCDC1 gene and the PAX6 gene may be the new targets for promoting the treatments of cataracts using magnesium intervention. Twit Text FOAVip MR-PheWAS for the causal effects of serum magnesium on multiple disease outcomes in Caucasian descent ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=34703991 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34703991 #FOAvip English Wikipedia <ref>{{Cite pmid|34703991}}</ref> MR-PheWAS for the causal effects of serum magnesium on multiple disease outcomes in Caucasian descent #MMPMID34703991 Li L; Yang W; Huang L; Feng X; Cheng H; Ge X; Zan G; Tan Y; Xiao L; Liu C; Chen X; Mo Z; Yang X iScience 2021[Oct]; 24 (10): 103191 PMID34703991show ga Magnesium is integral to many physiological processes, whereas variations in its levels, even within the normal range, can have critical implications for health. To explore the broad clinical effects of varying serum magnesium levels, we performed a two-sample Mendelian randomization and phenome-wide association study (MR-PheWAS) in the UK Biobank cohort. In total, MR-PheWAS analysis implicated a causal role of serum magnesium levels in five disease groups and six disease outcomes. In addition, our study indicated the gender-specific effects of nine disease groups/outcomes in MR estimated effects. The protein-protein interaction network demonstrated an interaction between the serum magnesium-associated gene DCDC1 and the cataract- associated gene PAX6. The present study verified several previously reported disease outcomes and identified novel potential disease outcomes for serum magnesium levels. The DCDC1 gene and the PAX6 gene may be the new targets for promoting the treatments of cataracts using magnesium intervention. äMR-PheWAS for the causal effects of serum magnesium on multiple diseas(epmc).pdf DeepDyve Pubget Overpricing