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10.1038/s41421-021-00329-3 http://scihub22266oqcxt.onion/10.1038/s41421-021-00329-3 34697287!8546144!34697287     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34697287&cmd=llinks): Failed to open stream: HTTP request failed! 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Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines |pdf=|usr=}}{{34697287}} gab.com Text Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines JO: Cell Discov http://www.kidney.de/pget.php?&tw=1&pmid=34697287 #FOAvip Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in COVID-19 patients, suggesting that vaccination mimicked an infection. Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) before and 28 days after the first inoculation also revealed consistent alterations in gene expression of many different immune cell types. Reduction of CD8(+) T cells and increase in classic monocyte contents were exemplary. Moreover, scRNA-seq revealed increased NF-kappaB signaling and reduced type I interferon responses, which were confirmed by biological assays and also had been reported to occur after SARS-CoV-2 infection with aggravating symptoms. Altogether, our study recommends additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders. Twit Text FOAVip Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines ????Cell Discov http://www.kidney.de/pget.php?&tw=1&pmid=34697287 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34697287 #FOAvip English Wikipedia <ref>{{Cite pmid|34697287}}</ref> Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines #MMPMID34697287 Liu J; Wang J; Xu J; Xia H; Wang Y; Zhang C; Chen W; Zhang H; Liu Q; Zhu R; Shi Y; Shen Z; Xing Z; Gao W; Zhou L; Shao J; Shi J; Yang X; Deng Y; Wu L; Lin Q; Zheng C; Zhu W; Wang C; Sun YE; Liu Z Cell Discov 2021[Oct]; 7 (1): 99 PMID34697287show ga Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in COVID-19 patients, suggesting that vaccination mimicked an infection. Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) before and 28 days after the first inoculation also revealed consistent alterations in gene expression of many different immune cell types. Reduction of CD8(+) T cells and increase in classic monocyte contents were exemplary. Moreover, scRNA-seq revealed increased NF-kappaB signaling and reduced type I interferon responses, which were confirmed by biological assays and also had been reported to occur after SARS-CoV-2 infection with aggravating symptoms. Altogether, our study recommends additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders. äComprehensive investigations revealed consistent pathophysiological al(epmc).pdf DeepDyve Pubget Overpricing