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10.3390/v13102056 http://scihub22266oqcxt.onion/10.3390/v13102056 34696485!8538446!34696485     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2021 ; 13 (10): ä Nephropedia Template TP {{tp|p=34696485|t=2021. SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro |pdf=|usr=}}{{34696485}} gab.com Text SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34696485 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the coronavirus disease 2019 (COVID-19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role in fighting against SARS-CoV-2 infection and directly influences the clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID-19 exhibit delayed and weak adaptive immune responses; however, the mechanism by which SARS-CoV-2 impedes adaptive immunity remains unclear. Here, by using an in vitro cell line, we report that the SARS-CoV-2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines. Twit Text FOAVip SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=34696485 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34696485 #FOAvip English Wikipedia <ref>{{Cite pmid|34696485}}</ref> SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro #MMPMID34696485 Jiang H; Mei YF Viruses 2021[Oct]; 13 (10): ä PMID34696485show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the coronavirus disease 2019 (COVID-19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role in fighting against SARS-CoV-2 infection and directly influences the clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID-19 exhibit delayed and weak adaptive immune responses; however, the mechanism by which SARS-CoV-2 impedes adaptive immunity remains unclear. Here, by using an in vitro cell line, we report that the SARS-CoV-2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines. |Adaptive Immunity/*immunology[MESH] |Antibodies, Neutralizing/blood/immunology[MESH] |Antibodies, Viral/blood/immunology[MESH] |BRCA1 Protein/antagonists & inhibitors[MESH] |CD4 Lymphocyte Count[MESH] |CD8-Positive T-Lymphocytes/immunology[MESH] |COVID-19 Vaccines/immunology[MESH] |COVID-19/*pathology[MESH] |Cell Line[MESH] |DNA Damage/genetics[MESH] |DNA Repair/*genetics[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunity, Humoral/immunology[MESH] |Immunosuppression Therapy[MESH] |SARS-CoV-2/genetics/*immunology[MESH] |Spike Glycoprotein, Coronavirus/*genetics/immunology[MESH] |T-Lymphocytes, Helper-Inducer/immunology[MESH] |Tumor Suppressor p53-Binding Protein 1/antagonists & inhibitors[MESH]SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombin(epmc).pdf DeepDyve Pubget Overpricing