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10.1093/gbe/evab240 http://scihub22266oqcxt.onion/10.1093/gbe/evab240 34694399!8586724!34694399     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genome+Biol+Evol 2021 ; 13 (11): ä Nephropedia Template TP {{tp|p=34694399|t=2021. ADAR Editing in Viruses: An Evolutionary Force to Reckon with |pdf=|usr=}}{{34694399}} gab.com Text ADAR Editing in Viruses: An Evolutionary Force to Reckon with JO: Genome Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=34694399 #FOAvip Adenosine Deaminases that Act on RNA (ADARs) are RNA editing enzymes that play a dynamic and nuanced role in regulating transcriptome and proteome diversity. This editing can be highly selective, affecting a specific site within a transcript, or nonselective, resulting in hyperediting. ADAR editing is important for regulating neural functions and autoimmunity, and has a key role in the innate immune response to viral infections, where editing can have a range of pro- or antiviral effects and can contribute to viral evolution. Here we examine the role of ADAR editing across a broad range of viral groups. We propose that the effect of ADAR editing on viral replication, whether pro- or antiviral, is better viewed as an axis rather than a binary, and that the specific position of a given virus on this axis is highly dependent on virus- and host-specific factors, and can change over the course of infection. However, more research needs to be devoted to understanding these dynamic factors and how they affect virus-ADAR interactions and viral evolution. Another area that warrants significant attention is the effect of virus-ADAR interactions on host-ADAR interactions, particularly in light of the crucial role of ADAR in regulating neural functions. Answering these questions will be essential to developing our understanding of the relationship between ADAR editing and viral infection. In turn, this will further our understanding of the effects of viruses such as SARS-CoV-2, as well as many others, and thereby influence our approach to treating these deadly diseases. Twit Text FOAVip ADAR Editing in Viruses: An Evolutionary Force to Reckon with ????Genome Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=34694399 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34694399 #FOAvip English Wikipedia <ref>{{Cite pmid|34694399}}</ref> ADAR Editing in Viruses: An Evolutionary Force to Reckon with #MMPMID34694399 Piontkivska H; Wales-McGrath B; Miyamoto M; Wayne ML Genome Biol Evol 2021[Nov]; 13 (11): ä PMID34694399show ga Adenosine Deaminases that Act on RNA (ADARs) are RNA editing enzymes that play a dynamic and nuanced role in regulating transcriptome and proteome diversity. This editing can be highly selective, affecting a specific site within a transcript, or nonselective, resulting in hyperediting. ADAR editing is important for regulating neural functions and autoimmunity, and has a key role in the innate immune response to viral infections, where editing can have a range of pro- or antiviral effects and can contribute to viral evolution. Here we examine the role of ADAR editing across a broad range of viral groups. We propose that the effect of ADAR editing on viral replication, whether pro- or antiviral, is better viewed as an axis rather than a binary, and that the specific position of a given virus on this axis is highly dependent on virus- and host-specific factors, and can change over the course of infection. However, more research needs to be devoted to understanding these dynamic factors and how they affect virus-ADAR interactions and viral evolution. Another area that warrants significant attention is the effect of virus-ADAR interactions on host-ADAR interactions, particularly in light of the crucial role of ADAR in regulating neural functions. Answering these questions will be essential to developing our understanding of the relationship between ADAR editing and viral infection. In turn, this will further our understanding of the effects of viruses such as SARS-CoV-2, as well as many others, and thereby influence our approach to treating these deadly diseases. |*RNA Editing[MESH] |Adenosine Deaminase/genetics/*metabolism[MESH] |Animals[MESH] |Evolution, Molecular[MESH] |Host-Pathogen Interactions/immunology[MESH] |Humans[MESH] |Immunity[MESH] |RNA Viruses/classification/*genetics/physiology[MESH] |RNA, Viral/genetics/metabolism[MESH]ADAR Editing in Viruses: An Evolutionary Force to Reckon with (epmc).pdf DeepDyve Pubget Overpricing