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10.3389/fphys.2021.723224

http://scihub22266oqcxt.onion/10.3389/fphys.2021.723224
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suck abstract from ncbi


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pmid34690800      Front+Physiol 2021 ; 12 (ä): 723224
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  • Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development #MMPMID34690800
  • Griffiths WJ; Wang Y
  • Front Physiol 2021[]; 12 (ä): 723224 PMID34690800show ga
  • In this article we discuss the concept of accessible plasma membrane cholesterol and its involvement as a signalling molecule. Changes in plasma membrane accessible cholesterol, although only being minor in the context of total cholesterol plasma membrane cholesterol and total cell cholesterol, are a key regulator of overall cellular cholesterol homeostasis by the SREBP pathway. Accessible cholesterol also provides the second messenger between patched 1 and smoothened in the hedgehog signalling pathway important during development, and its depletion may provide a mechanism of resistance to microbial pathogens including SARS-CoV-2. We revise the hypothesis that oxysterols are a signalling form of cholesterol, in this instance as a rapidly acting and paracrine version of accessible cholesterol.
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