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10.1016/j.jaapos.2021.06.004

http://scihub22266oqcxt.onion/10.1016/j.jaapos.2021.06.004
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suck abstract from ncbi


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pmid34687877      J+AAPOS 2021 ; 25 (6): 325.e1-325.e6
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  • Retinal and peripapillary vessel density increase in recovered COVID-19 children by optical coherence tomography angiography #MMPMID34687877
  • Guemes-Villahoz N; Burgos-Blasco B; Perez-Garcia P; Fernandez-Vigo JI; Morales-Fernandez L; Donate-Lopez J; Ramos-Amador JT; Garcia-Feijoo J
  • J AAPOS 2021[Dec]; 25 (6): 325.e1-325.e6 PMID34687877show ga
  • PURPOSE: To evaluate retinal vascular changes in children who have recovered from coronavirus disease (COVID-19) using optical coherence tomography angiography (OCTA) and to compare the results with age-matched healthy children. METHODS: In this cross-sectional case-control study, children 6-18 years of age with laboratory-confirmed SARS-CoV-2 infection were compared with historic healthy controls. All participants underwent ophthalmological examination, including fundus photography and OCTA of the macular region and optic disk. COVID-19 children were examined 4-8 weeks after COVID-19 diagnoses. Demographic data, medical history, and COVID-19 symptoms were noted. OCTA parameters in the superficial capillary plexus (SCP) were analyzed according to ETDRS sectors and peripapillary quadrants. RESULTS: A total of 72 patients were included: 27 recovered COVID-19 children and 45 controls. Mean age for cases was 11.96 +/- 3.8 years (18 females [66%]); for controls, 11.02 +/- 2.0 years (29 females [64%]). Macular OCTA of the SCP showed a significant increase in retinal vessel density (VD) in recovered COVID-19 children compared with healthy controls in the inner ring (P = 0.001). Macular perfusion density (mPD) was also increased in the inner ring (P = 0.001). Peripapillary OCTA evidenced a significant higher flux index (FI) in all four quadrants (P < 0.001). CONCLUSIONS: Recovered COVID-19 children present increased retinal VD, mPD, and peripapillary FI shortly after recovery. Since the retinal vasculature is considered a unique window to assess microvascular changes, these findings may represent a potential in vivo biomarker of vascular abnormalities in COVID-19 children in other organs.
  • |*COVID-19[MESH]
  • |*Tomography, Optical Coherence[MESH]
  • |Adolescent[MESH]
  • |Case-Control Studies[MESH]
  • |Child[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Female[MESH]
  • |Fluorescein Angiography[MESH]
  • |Humans[MESH]
  • |Retinal Vessels/diagnostic imaging[MESH]


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