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10.1093/jmcb/mjab067 http://scihub22266oqcxt.onion/10.1093/jmcb/mjab067 34687295!8574305!34687295     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Cell+Biol 2021 ; 13 (10): 748-759 Nephropedia Template TP {{tp|p=34687295|t=2021. Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNA |pdf=|usr=}}{{34687295}} gab.com Text Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNA JO: J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=34687295 #FOAvip Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has become a global public health crisis. Some patients who have recovered from COVID-19 subsequently test positive again for SARS-CoV-2 RNA after discharge from hospital. How such retest-positive (RTP) patients become infected again is not known. In this study, 30 RTP patients, 20 convalescent patients, and 20 healthy controls were enrolled for the analysis of immunological characteristics of their peripheral blood mononuclear cells. We found that absolute numbers of CD4+ T cells, CD8+ T cells, and natural killer cells were not substantially decreased in RTP patients, but the expression of activation markers on these cells was significantly reduced. The percentage of granzyme B-producing T cells was also lower in RTP patients than in convalescent patients. Through transcriptome sequencing, we demonstrated that high expression of inhibitor of differentiation 1 (ID1) and low expression of interferon-induced transmembrane protein 10 (IFITM10) were associated with insufficient activation of immune cells and the occurrence of RTP. These findings provide insight into the impaired immune function associated with COVID-19 and the pathogenesis of RTP, which may contribute to a better understanding of the mechanisms underlying RTP. Twit Text FOAVip Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNA ????J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=34687295 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34687295 #FOAvip English Wikipedia <ref>{{Cite pmid|34687295}}</ref> Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNA #MMPMID34687295 Wang D; Wang D; Huang M; Zheng X; Shen Y; Fu B; Zhao H; Chen X; Peng P; Zhu Q; Zhou Y; Zhang J; Tian Z; Guan W; Wang G; Wei H J Mol Cell Biol 2021[Dec]; 13 (10): 748-759 PMID34687295show ga Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has become a global public health crisis. Some patients who have recovered from COVID-19 subsequently test positive again for SARS-CoV-2 RNA after discharge from hospital. How such retest-positive (RTP) patients become infected again is not known. In this study, 30 RTP patients, 20 convalescent patients, and 20 healthy controls were enrolled for the analysis of immunological characteristics of their peripheral blood mononuclear cells. We found that absolute numbers of CD4+ T cells, CD8+ T cells, and natural killer cells were not substantially decreased in RTP patients, but the expression of activation markers on these cells was significantly reduced. The percentage of granzyme B-producing T cells was also lower in RTP patients than in convalescent patients. Through transcriptome sequencing, we demonstrated that high expression of inhibitor of differentiation 1 (ID1) and low expression of interferon-induced transmembrane protein 10 (IFITM10) were associated with insufficient activation of immune cells and the occurrence of RTP. These findings provide insight into the impaired immune function associated with COVID-19 and the pathogenesis of RTP, which may contribute to a better understanding of the mechanisms underlying RTP. |*Convalescence[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antigens, CD/genetics/immunology[MESH] |COVID-19 Nucleic Acid Testing[MESH] |COVID-19/genetics/*immunology/virology[MESH] |Case-Control Studies[MESH] |Female[MESH] |Healthy Volunteers[MESH] |Host-Pathogen Interactions/genetics/immunology[MESH] |Humans[MESH] |Inhibitor of Differentiation Protein 1/genetics/immunology[MESH] |Lymphocyte Activation Gene 3 Protein[MESH] |Male[MESH] |Middle Aged[MESH] |Patient Readmission[MESH] |RNA, Viral/isolation & purification[MESH] |Reinfection/genetics/*immunology/virology[MESH] |SARS-CoV-2/genetics/*immunology/isolation & purification[MESH] |Transcriptome/*immunology[MESH]Transcriptomic characteristics and impaired immune function of patient(epmc).pdf DeepDyve Pubget Overpricing