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10.3390/ijms222010984 http://scihub22266oqcxt.onion/10.3390/ijms222010984 34681641!8538215!34681641     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (20): ä Nephropedia Template TP {{tp|p=34681641|t=2021. G-Quadruplex Targeting in the Fight against Viruses: An Update |pdf=|usr=}}{{34681641}} gab.com Text G-Quadruplex Targeting in the Fight against Viruses: An Update JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34681641 #FOAvip G-quadruplexes (G4s) are noncanonical nucleic acid structures involved in the regulation of key cellular processes, such as transcription and replication. Since their discovery, G4s have been mainly investigated for their role in cancer and as targets in anticancer therapy. More recently, exploration of the presence and role of G4s in viral genomes has led to the discovery of G4-regulated key viral pathways. In this context, employment of selective G4 ligands has helped to understand the complexity of G4-mediated mechanisms in the viral life cycle, and highlighted the possibility to target viral G4s as an emerging antiviral approach. Research in this field is growing at a fast pace, providing increasing evidence of the antiviral activity of old and new G4 ligands. This review aims to provide a punctual update on the literature on G4 ligands exploited in virology. Different classes of G4 binders are described, with emphasis on possible antiviral applications in emerging diseases, such as the current COVID-19 pandemic. Strengths and weaknesses of G4 targeting in viruses are discussed. Twit Text FOAVip G-Quadruplex Targeting in the Fight against Viruses: An Update ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34681641 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34681641 #FOAvip English Wikipedia <ref>{{Cite pmid|34681641}}</ref> G-Quadruplex Targeting in the Fight against Viruses: An Update #MMPMID34681641 Ruggiero E; Zanin I; Terreri M; Richter SN Int J Mol Sci 2021[Oct]; 22 (20): ä PMID34681641show ga G-quadruplexes (G4s) are noncanonical nucleic acid structures involved in the regulation of key cellular processes, such as transcription and replication. Since their discovery, G4s have been mainly investigated for their role in cancer and as targets in anticancer therapy. More recently, exploration of the presence and role of G4s in viral genomes has led to the discovery of G4-regulated key viral pathways. In this context, employment of selective G4 ligands has helped to understand the complexity of G4-mediated mechanisms in the viral life cycle, and highlighted the possibility to target viral G4s as an emerging antiviral approach. Research in this field is growing at a fast pace, providing increasing evidence of the antiviral activity of old and new G4 ligands. This review aims to provide a punctual update on the literature on G4 ligands exploited in virology. Different classes of G4 binders are described, with emphasis on possible antiviral applications in emerging diseases, such as the current COVID-19 pandemic. Strengths and weaknesses of G4 targeting in viruses are discussed. |*G-Quadruplexes[MESH] |Antiviral Agents/*chemistry/therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/virology[MESH] |DNA, Viral/chemistry/metabolism[MESH] |Humans[MESH] |Ligands[MESH] |MicroRNAs/antagonists & inhibitors/metabolism[MESH] |RNA, Viral/chemistry/metabolism[MESH] |SARS-CoV-2/isolation & purification[MESH]G-Quadruplex Targeting in the Fight against Viruses: An Update (epmc).pdf DeepDyve Pubget Overpricing