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10.3390/ijms222010933

http://scihub22266oqcxt.onion/10.3390/ijms222010933
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34681591!8535529!34681591
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suck abstract from ncbi


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pmid34681591      Int+J+Mol+Sci 2021 ; 22 (20): ä
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  • Mechanism of Phosgene-Induced Acute Lung Injury and Treatment Strategy #MMPMID34681591
  • Lu Q; Huang S; Meng X; Zhang J; Yu S; Li J; Shi M; Fan H; Zhao Y
  • Int J Mol Sci 2021[Oct]; 22 (20): ä PMID34681591show ga
  • Phosgene (COCl(2)) was once used as a classic suffocation poison and currently plays an essential role in industrial production. Due to its high toxicity, the problem of poisoning caused by leakage during production, storage, and use cannot be ignored. Phosgene mainly acts on the lungs, causing long-lasting respiratory depression, refractory pulmonary edema, and other related lung injuries, which may cause acute respiratory distress syndrome or even death in severe cases. Due to the high mortality, poor prognosis, and frequent sequelae, targeted therapies for phosgene exposure are needed. However, there is currently no specific antidote for phosgene poisoning. This paper reviews the literature on the mechanism and treatment strategies to explore new ideas for the treatment of phosgene poisoning.
  • |Acute Lung Injury/chemically induced/metabolism/*therapy[MESH]
  • |Antioxidants/therapeutic use[MESH]
  • |Cell Membrane/drug effects/metabolism[MESH]
  • |Extracorporeal Membrane Oxygenation[MESH]
  • |Glucocorticoids/therapeutic use[MESH]
  • |Mesenchymal Stem Cell Transplantation[MESH]
  • |Oxidative Stress/drug effects[MESH]
  • |Phosgene/*toxicity[MESH]
  • |Prognosis[MESH]


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