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10.1038/s41587-021-01065-5

http://scihub22266oqcxt.onion/10.1038/s41587-021-01065-5
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suck abstract from ncbi


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pmid34675424      Nat+Biotechnol 2022 ; 40 (3): 374-381
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  • Single-cell profiling of proteins and chromatin accessibility using PHAGE-ATAC #MMPMID34675424
  • Fiskin E; Lareau CA; Ludwig LS; Eraslan G; Liu F; Ring AM; Xavier RJ; Regev A
  • Nat Biotechnol 2022[Mar]; 40 (3): 374-381 PMID34675424show ga
  • Multimodal measurements of single-cell profiles are proving increasingly useful for characterizing cell states and regulatory mechanisms. In the present study, we developed PHAGE-ATAC (Assay for Transposase-Accessible Chromatin), a massively parallel droplet-based method that uses phage displaying, engineered, camelid single-domain antibodies ('nanobodies') for simultaneous single-cell measurements of protein levels and chromatin accessibility profiles, and mitochondrial DNA-based clonal tracing. We use PHAGE-ATAC for multimodal analysis in primary human immune cells, sample multiplexing, intracellular protein analysis and the detection of SARS-CoV-2 spike protein in human cell populations. Finally, we construct a synthetic high-complexity phage library for selection of antigen-specific nanobodies that bind cells of particular molecular profiles, opening an avenue for protein detection, cell characterization and screening with single-cell genomics.
  • |*Bacteriophages/genetics[MESH]
  • |*COVID-19[MESH]
  • |Chromatin/genetics[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2[MESH]
  • |Single-Cell Analysis/methods[MESH]


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