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10.1038/s41598-021-00286-7 http://scihub22266oqcxt.onion/10.1038/s41598-021-00286-7 34675292!8531370!34675292     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 20866 Nephropedia Template TP {{tp|p=34675292|t=2021. Inferring a causal relationship between ceramide levels and COVID-19 respiratory distress |pdf=|usr=}}{{34675292}} gab.com Text Inferring a causal relationship between ceramide levels and COVID-19 respiratory distress JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34675292 #FOAvip A causal relationship between plasma ceramide concentration and respiratory distress symptoms in COVID-19 patients is inferred. In this study, plasma samples of 52 individuals infected with COVID-19 were utilized in a lipidomic analysis. Lipids belonging to the ceramide class exhibited a 400-fold increase in total plasma concentration in infected patients. Further analysis led to the demonstration of concentration dependency for severe COVID-19 respiratory symptoms in a subclass of ceramides. The subclasses Cer(d18:0/24:1), Cer(d18:1/24:1), and Cer(d18:1/22:0) were shown to be increased by 48-, 40-, and 33-fold, respectively, in infected plasma samples and to 116-, 91- and 50-fold, respectively, in plasma samples with respiratory distress. Hence, monitoring plasma ceramide concentration, can be a valuable tool for measuring effects of therapies on COVID-19 respiratory distress patients. Twit Text FOAVip Inferring a causal relationship between ceramide levels and COVID-19 respiratory distress ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34675292 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34675292 #FOAvip English Wikipedia <ref>{{Cite pmid|34675292}}</ref> Inferring a causal relationship between ceramide levels and COVID-19 respiratory distress #MMPMID34675292 Khodadoust MM Sci Rep 2021[Oct]; 11 (1): 20866 PMID34675292show ga A causal relationship between plasma ceramide concentration and respiratory distress symptoms in COVID-19 patients is inferred. In this study, plasma samples of 52 individuals infected with COVID-19 were utilized in a lipidomic analysis. Lipids belonging to the ceramide class exhibited a 400-fold increase in total plasma concentration in infected patients. Further analysis led to the demonstration of concentration dependency for severe COVID-19 respiratory symptoms in a subclass of ceramides. The subclasses Cer(d18:0/24:1), Cer(d18:1/24:1), and Cer(d18:1/22:0) were shown to be increased by 48-, 40-, and 33-fold, respectively, in infected plasma samples and to 116-, 91- and 50-fold, respectively, in plasma samples with respiratory distress. Hence, monitoring plasma ceramide concentration, can be a valuable tool for measuring effects of therapies on COVID-19 respiratory distress patients. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/*blood/*complications[MESH] |Ceramides/*blood[MESH] |Chromatography, Liquid[MESH] |Drug Design[MESH] |Female[MESH] |Humans[MESH] |Ions[MESH] |Lipids/chemistry[MESH] |Male[MESH] |Metabolomics[MESH] |Middle Aged[MESH] |Principal Component Analysis[MESH] |Respiratory Distress Syndrome/*blood/*complications[MESH] |Software[MESH] |Tandem Mass Spectrometry[MESH] |Translational Research, Biomedical/methods[MESH] |Virus Diseases[MESH]Inferring a causal relationship between ceramide levels and COVID-19 r(epmc).pdf DeepDyve Pubget Overpricing