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10.1038/s41577-021-00633-9 http://scihub22266oqcxt.onion/10.1038/s41577-021-00633-9 34671122!8527296!34671122     free     free     free       Nat+Rev+Immunol 2022 ; 22 (8): 471-483 Nephropedia Template TP {{tp|p=34671122|t=2022. The type I interferonopathies: 10 years on |pdf=|usr=}}{{34671122}} gab.com Text The type I interferonopathies: 10 years on JO: Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34671122 #FOAvip As brutally demonstrated by the COVID-19 pandemic, an effective immune system is essential for survival. Developed over evolutionary time, viral nucleic acid detection is a central pillar in the defensive armamentarium used to combat foreign microbial invasion. To ensure cellular homeostasis, such a strategy necessitates the efficient discrimination of pathogen-derived DNA and RNA from that of the host. In 2011, it was suggested that an upregulation of type I interferon signalling might serve as a defining feature of a novel set of Mendelian inborn errors of immunity, where antiviral sensors are triggered by host nucleic acids due to a failure of self versus non-self discrimination. These rare disorders have played a surprisingly significant role in informing our understanding of innate immunity and the relevance of type I interferon signalling for human health and disease. Here we consider what we have learned in this time, and how the field may develop in the future. Twit Text FOAVip The type I interferonopathies: 10 years on ????Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34671122 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34671122 #FOAvip English Wikipedia <ref>{{Cite pmid|34671122}}</ref> The type I interferonopathies: 10 years on #MMPMID34671122 Crow YJ; Stetson DB Nat Rev Immunol 2022[Aug]; 22 (8): 471-483 PMID34671122show ga As brutally demonstrated by the COVID-19 pandemic, an effective immune system is essential for survival. Developed over evolutionary time, viral nucleic acid detection is a central pillar in the defensive armamentarium used to combat foreign microbial invasion. To ensure cellular homeostasis, such a strategy necessitates the efficient discrimination of pathogen-derived DNA and RNA from that of the host. In 2011, it was suggested that an upregulation of type I interferon signalling might serve as a defining feature of a novel set of Mendelian inborn errors of immunity, where antiviral sensors are triggered by host nucleic acids due to a failure of self versus non-self discrimination. These rare disorders have played a surprisingly significant role in informing our understanding of innate immunity and the relevance of type I interferon signalling for human health and disease. Here we consider what we have learned in this time, and how the field may develop in the future. |*COVID-19[MESH] |*Interferon Type I/genetics[MESH] |*Nucleic Acids[MESH] |Humans[MESH] |Immunity, Innate[MESH]The type I interferonopathies: 10 years on (epmc).pdf DeepDyve Pubget Overpricing