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  • Harnessing autophagy to fight SARS-CoV-2: An update in view of recent drug development efforts #MMPMID34668225
  • Rein T
  • J Cell Biochem 2022[Feb]; 123 (2): 155-160 PMID34668225show ga
  • Drug repurposing is an attractive option for identifying new treatment strategies, in particular in extraordinary situations of urgent need such as the current coronavirus disease 2019 (Covid-19) pandemic. Recently, the World Health Organization announced testing of three drugs as potential Covid-19 therapeutics that are known for their dampening effect on the immune system. Thus, the underlying concept of selecting these drugs is to temper the potentially life-threatening overshooting of the immune system reacting to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. This viewpoint discusses the possibility that the impact of these and other drugs on autophagy contributes to their therapeutic effect by hampering the SARS-CoV-2 life cycle.
  • |*Drug Repositioning[MESH]
  • |*Pandemics[MESH]
  • |Antidepressive Agents/pharmacology[MESH]
  • |Antiviral Agents/*pharmacology/therapeutic use[MESH]
  • |Artesunate/*pharmacology/therapeutic use[MESH]
  • |Autophagy/*drug effects[MESH]
  • |COVID-19/*drug therapy[MESH]
  • |Chloroquine/pharmacology[MESH]
  • |Drug Development[MESH]
  • |Endoplasmic Reticulum/drug effects/physiology/virology[MESH]
  • |Endosomes/drug effects/virology[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/pharmacology[MESH]
  • |Imatinib Mesylate/*pharmacology/therapeutic use[MESH]
  • |Infliximab/*pharmacology/therapeutic use[MESH]
  • |Intracellular Membranes/drug effects/physiology/virology[MESH]
  • |Ivermectin/pharmacology[MESH]
  • |Macrolides/pharmacology[MESH]
  • |Middle East Respiratory Syndrome Coronavirus/drug effects[MESH]
  • |Niclosamide/pharmacology/therapeutic use[MESH]
  • |RNA, Viral/metabolism[MESH]
  • |SARS-CoV-2/*drug effects/physiology[MESH]
  • |Virus Replication[MESH]

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  • suck abstract from ncbi

    155 2.123 2022