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10.3389/fmicb.2021.752214 http://scihub22266oqcxt.onion/10.3389/fmicb.2021.752214 34659188!8512706!34659188     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34659188&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34659188.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Microbiol 2021 ; 12 (ä): 752214 Nephropedia Template TP {{tp|p=34659188|t=2021. Coronavirus Nsp1: Immune Response Suppression and Protein Expression Inhibition |pdf=|usr=}}{{34659188}} gab.com Text Coronavirus Nsp1: Immune Response Suppression and Protein Expression Inhibition JO: Front Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=34659188 #FOAvip Coronaviruses have brought severe challenges to public health all over the world in the past 20years. SARS-CoV-2, the causative agent of the COVID-19 pandemic that has led to millions of deaths, belongs to the genus beta-coronavirus. Alpha- and beta-coronaviruses encode a unique protein, nonstructural protein 1 (Nsp1) that both suppresses host immune responses and reduces global gene expression levels in the host cells. As a key pathogenicity factor of coronaviruses, Nsp1 redirects the host translation machinery to increase synthesis of viral proteins. Through multiple mechanisms, coronaviruses impede host protein expression through Nsp1, while escaping inhibition to allow the translation of viral RNA. In this review, we discuss current data about suppression of the immune responses and inhibition of protein synthesis induced by coronavirus Nsp1, as well as the prospect of live-attenuated vaccine development with virulence-attenuated viruses with mutations in Nsp1. Twit Text FOAVip Coronavirus Nsp1: Immune Response Suppression and Protein Expression Inhibition ????Front Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=34659188 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34659188 #FOAvip English Wikipedia <ref>{{Cite pmid|34659188}}</ref> Coronavirus Nsp1: Immune Response Suppression and Protein Expression Inhibition #MMPMID34659188 Yuan S; Balaji S; Lomakin IB; Xiong Y Front Microbiol 2021[]; 12 (ä): 752214 PMID34659188show ga Coronaviruses have brought severe challenges to public health all over the world in the past 20years. SARS-CoV-2, the causative agent of the COVID-19 pandemic that has led to millions of deaths, belongs to the genus beta-coronavirus. Alpha- and beta-coronaviruses encode a unique protein, nonstructural protein 1 (Nsp1) that both suppresses host immune responses and reduces global gene expression levels in the host cells. As a key pathogenicity factor of coronaviruses, Nsp1 redirects the host translation machinery to increase synthesis of viral proteins. Through multiple mechanisms, coronaviruses impede host protein expression through Nsp1, while escaping inhibition to allow the translation of viral RNA. In this review, we discuss current data about suppression of the immune responses and inhibition of protein synthesis induced by coronavirus Nsp1, as well as the prospect of live-attenuated vaccine development with virulence-attenuated viruses with mutations in Nsp1. äCoronavirus Nsp1: Immune Response Suppression and Protein Expression I(epmc).pdf DeepDyve Pubget Overpricing