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10.1016/bs.ai.2021.08.003 http://scihub22266oqcxt.onion/10.1016/bs.ai.2021.08.003 34656289!8438590!34656289     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Immunol 2021 ; 151 (ä): 99-133 Nephropedia Template TP {{tp|p=34656289|t=2021. Antibody dependent enhancement: Unavoidable problems in vaccine development |pdf=|usr=}}{{34656289}} gab.com Text Antibody dependent enhancement: Unavoidable problems in vaccine development JO: Adv Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34656289 #FOAvip In some cases, antibodies can enhance virus entry and replication in cells. This phenomenon is called antibody-dependent infection enhancement (ADE). ADE not only promotes the virus to be recognized by the target cell and enters the target cell, but also affects the signal transmission in the target cell. Early formalin-inactivated virus vaccines such as aluminum adjuvants (RSV and measles) have been shown to induce ADE. Although there is no direct evidence that there is ADE in COVID-19, this potential risk is a huge challenge for prevention and vaccine development. This article focuses on the virus-induced ADE phenomenon and its molecular mechanism. It also summarizes various attempts in vaccine research and development to eliminate the ADE phenomenon, and proposes to avoid ADE in vaccine development from the perspective of antigens and adjuvants. Twit Text FOAVip Antibody dependent enhancement: Unavoidable problems in vaccine development ????Adv Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34656289 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34656289 #FOAvip English Wikipedia <ref>{{Cite pmid|34656289}}</ref> Antibody dependent enhancement: Unavoidable problems in vaccine development #MMPMID34656289 Xu L; Ma Z; Li Y; Pang Z; Xiao S Adv Immunol 2021[]; 151 (ä): 99-133 PMID34656289show ga In some cases, antibodies can enhance virus entry and replication in cells. This phenomenon is called antibody-dependent infection enhancement (ADE). ADE not only promotes the virus to be recognized by the target cell and enters the target cell, but also affects the signal transmission in the target cell. Early formalin-inactivated virus vaccines such as aluminum adjuvants (RSV and measles) have been shown to induce ADE. Although there is no direct evidence that there is ADE in COVID-19, this potential risk is a huge challenge for prevention and vaccine development. This article focuses on the virus-induced ADE phenomenon and its molecular mechanism. It also summarizes various attempts in vaccine research and development to eliminate the ADE phenomenon, and proposes to avoid ADE in vaccine development from the perspective of antigens and adjuvants. |*Antibody-Dependent Enhancement[MESH] |*COVID-19[MESH] |Antibodies, Viral[MESH] |Humans[MESH]Antibody dependent enhancement: Unavoidable problems in vaccine develo(epmc).pdf DeepDyve Pubget Overpricing